Risk Prediction and Its Intelligent Assessment for Cognitive Impairment Among Community-dwelling Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13,228
- 试验地点
- 1
- 主要终点
- AUC
研究概览
简要总结
Cognitive impairment is one of the core early signs of dementia, and it is also a key stage for community-based dementia prevention. Accurate and convenient prediction of cognitive impairment can help the community to identify and manage the high-risk population of dementia. Previous studies had developed several dementia predicting models, but such models may be not suitable for cognitive impairment prediction. Based on the national representative follow-up data of Chinese Longitudinal Healthy Longevity Survey (CLHLS), this project aims to develop and validate a brief cognitive impairment prediction algorithm among the community-dwelling elderly, using machine learning methods (such as Logistic regression, Naïve Bayes model, Extreme Gradient Boosting Tree and so on). Finally, based on the constructed model, an easy-to-use online intelligent assessment tool for predicting cognitive impairment risk will be developed. The general practitioners, social workers and the elderly would be invited to use the tool and we will revise the tool according to their suggestions and comments. This project is expected to provide scientific basis and technical support for community-based dementia prevention, and will also be useful for the elderly to easily understand their cognitive health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —(Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 65 or over at baseline;
- •With normal cognitive function at baseline (score ≥ 18 on the Chinese version of Mini-Mental State Examination, MMSE);
- •Completed MMSE assessment three years later;
- •Provided informed consent voluntarily.
排除标准
- •had a history of dementia or MMSE score < 18 at baseline;
- •lost to follow-up or without cognitive function assessment three years later;
- •Refused to participate the survey.
结局指标
主要结局
AUC
时间窗: an average of 3 years after baseline assessement
the AUC of the prediciton model based on the test data
次要结局
- sensitivity(an average of 3 years after baseline assessement)
- specificity(an average of 3 years after baseline assessement)
- negative predictive value(an average of 3 years after baseline assessement)
- positive predictive value(an average of 3 years after baseline assessement)
研究者
Xiaozhen LV
Associate Researcher
Peking University Sixth Hospital
