Sex Differences in Postoperative Sleep Quality and Inflammation in Patients Undergoing Video-Assisted Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 213
- 试验地点
- 1
- 主要终点
- sleep quality of first night after surgery
研究概览
简要总结
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. And sleep disruption also remains a challenging problem in surgical settings. Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patient's physical condition. The aim of the study was to investigate the effect of sex differences on postoperative pain, inflammation and sleep quality among patients who have undergone video-assisted thoracoscopic surgery under general anesthesia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-80 years old
- •ASA I-III
- •under general anesthesia
排除标准
- •patients with central nervous system and mental diseases;
- •patients with preoperative sleep disturbances;
- •patients with a history of sedative, analgesic, or antidepression drug use;
- •patients with sleep apnea or moderate and severe obstructive sleep apnea-hypopnea syndrome;
结局指标
主要结局
sleep quality of first night after surgery
时间窗: first night after surgery
Use Athens insomnia scale to test the sleep quality the first night after surgery
sleep quality of one night before surgery
时间窗: first night before surgery
Use Athens insomnia scale to test the sleep quality the first night before surgery
sleep quality of third night after surgery
时间窗: third night after surgery
Use Athens insomnia scale to test the sleep quality the third night after surgery
次要结局
- perioperative inflammation function(first days after surgery)
- visual analog scale(VAS) score after surgery(8 pm the first day after surgery)
- postoperative adverse effect(24 hours after surgery)
- Postoperative cognition evaluation(third day after surgery)
研究者
Yanchao Yang
principal investigator
Shengjing Hospital