Towards a minimally invasive approach of atypical lipomatous tumors: the MINIMALIST trial
- Conditions
- -Atypical lipomatous tumor-Well-differentiatied liposarcoma-Lipoma
- Registration Number
- NL-OMON27031
- Lead Sponsor
- Erasmus MC Cancer Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 238
Aged =18 years
-Primary or recurrent lipomatous tumor suspected for lipoma or atypical lipomatous tumor
-Adequate understanding of the Dutch or English language (to fill out the HRQoL questionnaires)
-Tumor localization in the mediastinum, retroperitoneum or testis/scrotum
-Diagnosis through excisional biopsy
-Any type of treatment for the current tumor (i.e. in case of recurrence, treatment of the prior tumor(s) is allowed)
-Signs/suspicion of dedifferentiation in the biopsy specimen at time of diagnosis
-Unable to undergo regular MRI-scans (for example because of a pacemaker, claustrophobia)
-Systemic treatment for any other concurrent malignancy
-Currently receiving radiotherapy at affected site for other concurrent disease
-Incapable to understand the study, to sign informed consent or to fill out the HRQoL-questionnaires
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study endpoint is the choice of treatment (i.e. AS or surgery) to determine the feasibility of AS and the occurrence of dedifferentiation to determine the safety. Dedifferentiation has to be pathologically proven upon biopsy or resection.
- Secondary Outcome Measures
Name Time Method