Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 497
- 试验地点
- 4
- 主要终点
- screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients
研究概览
简要总结
Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism
详细描述
Analysis about 50 genes in glutamate synapse
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •have a Pervasive Developmental Disorder
排除标准
- 未提供
研究组 & 干预措施
Minor control
auditory evoked potentials
干预措施: Auditory evoked potentials (Other)
Autism
Analysis of the glutamate synapse in autism
干预措施: DNA collection (Genetic)
Autism
Analysis of the glutamate synapse in autism
干预措施: Auditory evoked potentials (Other)
Autism
Analysis of the glutamate synapse in autism
干预措施: analysis of the glutamate synapse in autism (Genetic)
Relative
Analysis of the glutamate synapse in autism
干预措施: analysis of the glutamate synapse in autism (Genetic)
Relative
Analysis of the glutamate synapse in autism
干预措施: DNA collection (Genetic)
Relative
Analysis of the glutamate synapse in autism
干预措施: Auditory evoked potentials (Other)
Major control
DNA collection
干预措施: Auditory evoked potentials (Other)
Major control
DNA collection
干预措施: analysis of the glutamate synapse in autism (Genetic)
Major control
DNA collection
干预措施: DNA collection (Genetic)
结局指标
主要结局
screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients
时间窗: two years
次要结局
未报告次要终点