Association of Peripheral Atherosclerotic Burden With the Short-term and Long-term Outcome in Patients With Elective Myocardial Revascularisation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atherosclerosis
- Sponsor
- Medical University Innsbruck
- Enrollment
- 252
- Locations
- 1
- Primary Endpoint
- Association of morbidity with peripheral atherosclerotic volume
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The study is a prospective-observational, explorative single-centre cohort study aimed to examine the influence of the peripheral atherosclerotic plaque volume on short and long term morbidity and mortality in patient after coronary artery bypass grafting (CABG).
Atherosclerotic disease (IMT, plaque volume) will be measured with a ultrasound system (IMT measurements and 3D quantitative plaque volumetric). Hemodynamic and flow profiles of the internal thoracic arteries will be evaluated additionally with US. These parameters will be measured pre-CABG.
Morbidity will be evaluated using quality of life questionnaires (EQ-5D-3L, IPAQ). Major adverse cardiovascular events (MACE) will be the primary endpoint. The atherosclerotic burden will be compared with established risk scores (EuroSCORE, STS-Score, SYNTAX Score, FORECAST.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •no consent, prior carotid intervention
Outcomes
Primary Outcomes
Association of morbidity with peripheral atherosclerotic volume
Time Frame: 5 years
Morbidity will be evaluated with quality of life assessment ("EQ-5D-3L", "IPAQ"
Association of MACE rates with peripheral atherosclerotic volume
Time Frame: 5 years
Secondary Outcomes
- Association of the duration of the operation with peripheral atherosclerotic volume(30 days)
- Comparison of predictive value of peripheral atherosclerotic volume with established risk scores for cardiovascular operations and interventions(1 year)
- Association of flow profiles of internal mammary artery with LIMA/RIMA graft patency rates(5 years)
- Association of the hospitalization duration with peripheral atherosclerotic volume(30 days)
- Association of the aortic clamp time with peripheral atherosclerotic volume(30 days)
- Association of the ICU stay with peripheral atherosclerotic volume(30 days)