Association of Peripheral Atherosclerotic Burden With the Short-term and Long-term Outcome in Patients With Elective Myocardial Revascularisation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 252
- 试验地点
- 1
- 主要终点
- Association of morbidity with peripheral atherosclerotic volume
研究概览
简要总结
The study is a prospective-observational, explorative single-centre cohort study aimed to examine the influence of the peripheral atherosclerotic plaque volume on short and long term morbidity and mortality in patient after coronary artery bypass grafting (CABG).
Atherosclerotic disease (IMT, plaque volume) will be measured with a ultrasound system (IMT measurements and 3D quantitative plaque volumetric). Hemodynamic and flow profiles of the internal thoracic arteries will be evaluated additionally with US. These parameters will be measured pre-CABG.
Morbidity will be evaluated using quality of life questionnaires (EQ-5D-3L, IPAQ). Major adverse cardiovascular events (MACE) will be the primary endpoint. The atherosclerotic burden will be compared with established risk scores (EuroSCORE, STS-Score, SYNTAX Score, FORECAST.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •no consent, prior carotid intervention
结局指标
主要结局
Association of morbidity with peripheral atherosclerotic volume
时间窗: 5 years
Morbidity will be evaluated with quality of life assessment ("EQ-5D-3L", "IPAQ"
Association of MACE rates with peripheral atherosclerotic volume
时间窗: 5 years
次要结局
- Association of the duration of the operation with peripheral atherosclerotic volume(30 days)
- Comparison of predictive value of peripheral atherosclerotic volume with established risk scores for cardiovascular operations and interventions(1 year)
- Association of flow profiles of internal mammary artery with LIMA/RIMA graft patency rates(5 years)
- Association of the hospitalization duration with peripheral atherosclerotic volume(30 days)
- Association of the aortic clamp time with peripheral atherosclerotic volume(30 days)
- Association of the ICU stay with peripheral atherosclerotic volume(30 days)