Functional brain imaging of the influence of interoceptive awareness and autonomic nervous system function in pain processing in fibromyalgia - Imaging of autonomic nervous system function in fibromyalgia

niversitair Medisch Centrum Utrecht0 个研究点目标入组 154 人开始时间: 待定最近更新: 2024年8月12日

适应症

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•Only female subjects will be recruited since most patients with fibromyalgia are female (~85%). Fibromyalgia patients will have a diagnosis of primary fibromyalgia according to the American College of Rheumatology classification criteria. Control subjects will be healthy. Eligible participants will be: between 20-50 years of age, in their pre-menopausal state with a recurrent menstrual cycle, right-handed, and speak Dutch fluently. Further, participants should adequately perceive stimuli as painful and non-painful. This last criterion will be determined in the pre-fMRI screening session and will serve as an inclusion criterion for the next visit. Healthy participants will be matched to fibromyalgia patients on age and educational level. All participants will sign informed consent.

•Exclusion criteria are: cognitive impairment as tested by the Mini-Mental State Exam, if the painful stimulation fails to reach appropriate scores on a 0-100 visual analog scale of pain intensity, if not able to undergo MRI scanning, for example due to metal parts in or on the body or claustrophobia, if pregnant, current use of sedative psychotropic medications, when there is any serious injury to the body regions to be tested, serious health problems other than fibromyalgia as assessed with a health questionnaire.

发起方

niversitair Medisch Centrum Utrecht