Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy

Completed

• Conditions: Glaucoma; Pulmonary Hypertension

• Registration Number: NCT00452283
• Lead Sponsor: University of Colorado, Denver

Brief Summary

There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve. Pulmonary hypertension (PH)is a disease characterized by low oxygen levels in the blood and altered blood circulation. The decrease in oxygen delivery to the optic nerve could lead to the loss of nerve fiber layer(NFL)in the retina and the resulting visual field compromise. This situation is characteristic of glaucoma. The ability to identify NFL thinning early could lead to earlier diagnosis of glaucoma and more effective treatment to limit dysfunction from visual field loss.

We hypothesize that the rate of structural damage to the NFL, a feature of glaucoma, is higher in patients with PH than expected in healthy populations lacking this disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2007-03-23
• Study First Submitted QC: 2007-03-26
• Study First Posted: 2007-03-27
• Primary Completion: 2011-05
• Study Completion: 2011-05
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-29
• Last Update Posted: 2013-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• diagnosed with pulmonary hypertension
• between the ages of 18 and 80 years
• ability to undergo the various ocular exams.

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Exclusion Criteria

• patients with other diseases that could affect the nerve fiber layer
• special populations; ie children, pregnancy, lactating females, prisoners

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Occurence of nerve fiber layer abnormalities	Single Exam

Secondary Outcome Measures

Name	Time	Method
Optic Nerve Head Structure	Single Exam

Trial Locations

Locations (1)

University of Colorado Eye Center; 🇺🇸 Aurora, Colorado, United States