Evaluation of the effectiveness of adjunctive intra pocket delivery of injectable platelet concentrate (iPRF) in non surgical periodontal therapy-A randomized controlled split mouth trial

Periodontal disease is the sixth most prevalent health condition that affects humans. It is one of the important reasons for tooth loss, impacts the quality of life of individuals. Emerging evidence links it to several systemic life threatening conditions like cardiovascular disease and diabetes making it an important public health problem. The objective of the prospective intervention trial is to assess the effectiveness of intrapocket delivery of injectable platelet rich fibrin in the non surgical management of moderate to severe periodontitis when compared to conventional scaling root planing. These autologous platelet concentrate are suspensions of growth factors and when applied locally ,they can induce soft and hard tissue regeneration. Since the standard PRF is not entirely appropriate for injection ,a new injectable formulation of PRF(termed i-PRF)enables easier use of platelet concentrate in liquid state. Otherwise healthy adults with moderate to severe periodontitis who satisfies the inclusion criteria are included in the study.Eligible individuals are randomized into test and control groups by split mouth design. Conclusions will be drawn based on the results. Treatment of periodontal disease is complicated and expensive. Many patients require invasive procedures including regenerative therapy. Adjunctive approaches to conventional non surgical therapy has page  been investigated widely to avoid invasive surgical interventions. This study is such an attempt, where by an  adjuvant like autologous platelet concentrate is added to conventional nonsurgical therapy in order to assess whether there is any improvement in clinical outcomes when compared to non surgical therapy alone. If found beneficial it would be highly encouraging for the resource poor Indian health system.