Hemoglobin Concentration in Patients With an Acute Respiratory Distress Syndrome

Completed

• Conditions: ARDS, Human

• Registration Number: NCT03871166
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

Retrospective analysis of hemoglobin concentrations and red cell transfusion thresholds in patients with an Acute Respiratory Distress Syndrome (ARDS) admitted to an ARDS-center of a German university hospital.

Detailed Description

Transfusion of packed red blood cells is a common procedure in critically ill patients. In recent years it has been shown that for many patient populations a restrictive transfusion strategy is not inferior compared to a liberal transfusion strategy with regard to overall outcome.

So far it is unclear whether patients with an ARDS should receive blood transfusions according to a restrictive or liberal transfusion strategy. Besides pulmonary gar exchange and cardiac output, the hemoglobin concentration is an important determinant for oxygen delivery.

The aim of this retrospective observational study is to analyze if low levels of hemoglobin/a restrictive transfusion strategy and are associated with a different mortality compared to higher levels of hemoglobin/a liberal transfusion strategy in patients with an ARDS.

Study Timeline

• Study Start: 2018-08-01
• Study First Submitted: 2019-03-09
• Study First Submitted QC: 2019-03-09
• Study First Posted: 2019-03-12
• Primary Completion: 2020-07-01
• Study Completion: 2020-11-24
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-30
• Last Update Posted: 2021-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1044

Inclusion Criteria

• All adult patients with ARDS
• Admission to the Charité ARDS center

Exclusion Criteria

• All patients <18 years at the time of admission
• All patients with ARDS not admitted to the Charité ARDS center

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality	01/2007 - 12/2018	Mortality of patients with ARDS at 28 days according to transfusion threshold

Secondary Outcome Measures

Name	Time	Method
Failure-free days composites	01/2007 - 12/2018	Failure-free days composites according to transfusion threshold

Trial Locations

Locations (1)

Department of Anesthesiology and Operative Intensive Care Medicine Campus Virchow-Klinikum; 🇩🇪 Berlin, Germany