Hemoglobin Concentration in Patients With an Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,044
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Retrospective analysis of hemoglobin concentrations and red cell transfusion thresholds in patients with an Acute Respiratory Distress Syndrome (ARDS) admitted to an ARDS-center of a German university hospital.
详细描述
Transfusion of packed red blood cells is a common procedure in critically ill patients. In recent years it has been shown that for many patient populations a restrictive transfusion strategy is not inferior compared to a liberal transfusion strategy with regard to overall outcome.
So far it is unclear whether patients with an ARDS should receive blood transfusions according to a restrictive or liberal transfusion strategy. Besides pulmonary gar exchange and cardiac output, the hemoglobin concentration is an important determinant for oxygen delivery.
The aim of this retrospective observational study is to analyze if low levels of hemoglobin/a restrictive transfusion strategy and are associated with a different mortality compared to higher levels of hemoglobin/a liberal transfusion strategy in patients with an ARDS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult patients with ARDS
- •Admission to the Charité ARDS center
排除标准
- •All patients <18 years at the time of admission
- •All patients with ARDS not admitted to the Charité ARDS center
结局指标
主要结局
Mortality
时间窗: 01/2007 - 12/2018
Mortality of patients with ARDS at 28 days according to transfusion threshold
次要结局
- Failure-free days composites(01/2007 - 12/2018)
研究者
Jan Adriaan Graw
Principal Investigator
Charite University, Berlin, Germany