Early Detection of Myocardial Work Impairment in Patients With Overweight and Obesity (EARLY-MYO-OBESITY-II)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- investigate the change of global work efficiency (GWE) in overweight or obese patients
研究概览
简要总结
This prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.
详细描述
Obesity significantly increases the risk for heart failure. Early detection of preclinical cardiac dysfunction in overweight or obesity and understanding its association with insulin resistance are of great importance.Recently, a novel technique for myocardial work (MW) assessment has been introduced to evaluate myocardial performance. To date, change of MW has been described in several cardiac conditions including dilated cardiomyopathy, significant coronary arterial diseases, and hypertrophic cardiomyopathy, which implies regional or global myocardial dysfunction. In this study, we aimed to explore the alteration of MW in overweight or obese adults and to determine whether insulin resistance or other clinical risk factors may impact myocardial mechanics before impairment of systolic function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients were older than 18 without any cardiac symptoms.
- •The diagnosis of overweight was established when body mass index (BMI) of 25 to 30 kg/m
- •Obese was defined as a BMI of 30 kg/m2 or higher.
排除标准
- •diagnosis of type 2-Diabetes Mellitus according to the American Diabetes Association criteria;
- •left ventricular ejection fraction<50% on echocardiography;
- •arrythmia on electrocardiogram;
- •severe valvular stenosis or regurgitation;
- •history of coronary disease (defined as stenosis>50%) or myocardial infarction;
- •stress induced wall motion abnormality on echocardiography, coronary artery stenosis >50% on coronary CT or angiography with Framingham risk score of >10;
- •pacemaker or defibrillator implantation;
- •the presence of bundle branch block;
- •severe infection or renal dysfunction with an estimated glomerular filtration rate < 60 ml/min/1.73 m2);
- •inadequate image quality on echocardiography.
结局指标
主要结局
investigate the change of global work efficiency (GWE) in overweight or obese patients
时间窗: within 24 hours of the recruitment
GWE will be assessed in overweight or obese patients and compare with lean controls
investigate the change of global myocardial work index (GWI) in overweight or obese patients
时间窗: within 24 hours of the recruitment
GWI derived from echocardiography will be assessed in overweight or obese patients and compare with lean controls
investigate the change of global constructive work (GCW) in overweight or obese patients
时间窗: within 24 hours of the recruitment
GCW will be assessed in overweight or obese patients and compare with lean controls
investigate the change of global waste work (GWW) in overweight or obese patients
时间窗: within 24 hours of the recruitment
GWW will be assessed in overweight or obese patients and compare with lean controls
次要结局
未报告次要终点