Fistula-associated Anal Adenocarcinoma

Completed

• Conditions: Rectal Cancer

• Registration Number: NCT05381324
• Lead Sponsor: Medical University of Vienna

Brief Summary

The fistula-associated anal adenocarcinoma is rare in patients suffering from anal fistulas. There is only little data available for this patient collective making characterization and management of this disease difficult. Late diagnosis and advanced tumor stage at diagnosis result in poor clinical outcome. It is the purpose of this study to evaluate patients clinically diagnosed with a FAAC and to further perform a histopathological characterization of the available tumor specimen.

Detailed Description

All patients receiving surgery for an anal fistula in the years 1999 to 2019 at a tertiary university referral hospital were included in the analysis. A retrospective review of patients' charts was performed. Patients suffering from FAAC were eligible for histopathological analysis including immunohistochemistry and molecular profiling.

Study Timeline

• Study Start: 1999-01-01
• Primary Completion: 2019-12-31
• Status Verified: 2022-05
• Study Completion: 2022-05-01
• Study First Submitted: 2022-05-14
• Study First Submitted QC: 2022-05-14
• Last Update Submitted: 2022-05-14
• Study First Posted: 2022-05-19
• Last Update Posted: 2022-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1004

Inclusion Criteria

• anal fistula

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Exclusion Criteria

• previous cancer of the anal canal

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
fistula-associated anal adenocarcinoma (FAAC)	1999-2019	include and analyze all patients suffering from FAAC