Factors influencing seizure threshold in Electroconvulsive Therapy

Recruiting

Conditions: depression
depressive disorder
10027946

Registration Number: NL-OMON33666

Lead Sponsor: Alysis Zorggroep

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

The sample of subjects contains all patients referred for ECT to the Alysis Zorggroep, location Rijnstate Hospital, Arnhem, the Netherlands

Exclusion Criteria

a. age < 18 years;
b. no informed consent;
c. contraindications for dose-titration (e.g. life threatening condition of the patient, severe cardiovascular comorbidity);
d. contraindication for undergoing MRI (e.g. metals in the body, claustrophobic reactions, patient cannot lay still).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>a. Level of IST and level of seizure threshold at every 6th ECT-session;<br /><br>b. Thickness of the skull and scalp; volume and amount of white matter<br /><br>hyperintensities (WMH); cortical thickness; volumes of gray and white matter;<br /><br>and volume of cerebrospinal fluid (CSF) using magnetic resonance imaging (MRI);<br /><br>c. Resting state functional connectivity using blood oxygen level-dependent<br /><br>signals (BOLD) on functional MRI (fMRI) of specific areas;<br /><br>d. Amount of axonal density (fractional anisotropy) as measured with<br /><br>Diffusion Tensor Imaging (DTI) of specific areas.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The association between IST, *ST, demographic, clinical, and brain<br /><br>morphological and functional predictors and effectiveness of ECT.</p><br>