Clinical Research for the Correlation of PD-L1 Expression in Non-small Lung Cancer Tissue and Peripheral Blood T Cell and Serum.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- The match rate of PD-L1 protein expression in non-small lung cancer tissue and peripheral blood T cell .
研究概览
简要总结
The detection of tissue PD-L1 immunohistochemistry in Non-small cell lung cancer (NSCLC) has an important role in guiding for the treatment of immune detection point. At the same time,tissue detection is time-consuming and laborious, liquid biopsy can reflect the information of tumor tissue,PD-L1 expression in serum and peripheral blood T cell are expected to be simple, rapid, non-invasive means of detection. The project is planned to explore the correlation of PD-L1 expression in non-small lung cancer tissue and peripheral blood T cell and serum..The investigators have designed to detected the expression levels of PD-L1 protein in cancer tissue and detected the expression levels of PD-L1 in peripheral blood T cell and serum.By using variance analysis of repeated measures design information. Thus exploring the correlation of PD-L1 expression in non-small lung cancer tissue and peripheral blood T cell and serum,guiding clinical practice of immunotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pathological histology and/or cytology confirmed non-small lung cancer;
- •Voluntarily enrolled to participate in,better compliance, cooperate with experimental observations, and sign informed consent.
排除标准
- •Vital organs (e.g., heart, liver, kidney) have serious dysfunction;
- •Patients with a history of autoimmune disease;
- •Patients with participating in other clinical trials at the same time;
- •Other cases that researchers believe that patients should not participate in the present trial.
结局指标
主要结局
The match rate of PD-L1 protein expression in non-small lung cancer tissue and peripheral blood T cell .
时间窗: up to two years
consistency
The match rate of PD-L1 protein expression in non-small lung cancer tissue and serum.
时间窗: up to two years
consistency
次要结局
未报告次要终点
研究者
Jianguo Sun
Deputy Director,Head of Oncology department, Principal Investigator, Clinical Professor
Xinqiao Hospital of Chongqing