Exploring the use of venous blood samples for diagnosis and monitoring of patients with pulmonary hypertension, and determining the genetic base of disease.
Recruiting
- Conditions
- elevated lung pressurePulmonary Hypertension100822061000751010057166
- Registration Number
- NL-OMON55700
- Lead Sponsor
- ongziekten
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1600
Inclusion Criteria
Patients with (suspected) PH who are diagnosed with PH and/or undergo
diagnostic right heart catheterization in our clinic are eligible for our
study. PH is diagnosed conform ESC/ERS guidelines. We include treated and
untreated patients. In addition we aim to include an age and gender matched
control population containing persons with a normal hemodynamic profile. For
this we'll ask volunteers as well as patient suspected of heart disease but
with hemodynamic profile and partners, friends and/or family members
accompanying the patient in the clinic. Our goal is to form an age matched
population.
Exclusion Criteria
Not applicable. Control persons with co-morbidities can serve as a control for
patients with significant co-morbidity.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main objective of the study is to explore the use of peripheral blood to<br /><br>yield biomarkers for diagnostic and monitoring purposes in PH. For this we will<br /><br>use platelets and plasma, PBMCs, and ECFCs. Secondary objectives of this study<br /><br>are: </p><br>
- Secondary Outcome Measures
Name Time Method