Camera monitoring of circulation dynamics using skin perfusion pattern of lower limbs
Not Applicable
- Conditions
- Perfusion of lower limbsCirculatory System
- Registration Number
- ISRCTN10417167
- Lead Sponsor
- niversity of Oxford
- Brief Summary
2020 protocol in https://pubmed.ncbi.nlm.nih.gov/32532774/ (added 15/06/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Healthy males and females between the ages of 18 to 65
Exclusion Criteria
1. Patient whose anatomy, condition, or other required monitoring precludes the use of the camera equipment or thoracic bioimpedance monitor kit. Examples include skin disorders such as eczema, scleroderma or psoriasis
2. Allergy to silver chloride ECG sensors
3. Hyperthyroidism (intravenous phenylephrine contraindicated)
4. Any regular medication except combined oral contraceptives
5. Pregnant or breastfeeding
6. History or current psychiatric illness
7. History or current neurological conditions (e.g. epilepsy)
8. History of cardiovascular disease making phenylephrine or GTN unsafe
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Skin perfusion pattern at rest and change to the pattern post-exposure to phenylephrine and glyceryl trinitrate (GTN). Measured using composite measures from three different cameras measuring in visible, near-infrared, and infrared spectrum. Measures taken will include the strength of pulsatile signal measured at skin surface, absolute skin colour change when under constant lighting and angle, skin surface temperature gradient from proximal to distal areas, blood flow measurement using laser speckle contrast imager. Measurements will be taken at baseline, at one-minute intervals with increasing dose of phenylephrine and GTN, and at stable infusion maximal dose.
- Secondary Outcome Measures
Name Time Method