Heart and lung responses to exercise in adolescents born extremely preterm

Not Applicable

• Conditions: Extremely Preterm Birth; Extremely Low Birth Weight; Cardiovascular - Normal development and function of the cardiovascular system; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12619000539134
• Lead Sponsor: Murdoch Children's Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-04-04
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

Adolescents, aged 14-15 years, who were born EP/ELBW who are current participants in the ongoing VICS study 2005
-Adolescents, age 14 years, who were born at term and are participants as age/sex match controls in the ongoing VICS study 2005

Exclusion Criteria

-Participants will be excluded if they have limitations which prevent them from exercising safely including…
-Participants deemed moderate or high risk for cardiovascular, metabolic, and pulmonary disease
-Participants with diagnosed cardiovascular, metabolic, and pulmonary disease,
-Musculoskeletal injuries that prevent the participant from participating in everyday life
- Participants on antihypertensive medication
- Participants with a physical or intellectual impairment that would interfere with their ability to be involved in the exercise intervention, such as diagnosed > gross motor function classification system I cerebral palsy, developmental coordination disorder, and autism
-Participants with claustrophobia, as having a measurement MRI would be distressing for such individuals

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiopulmonary capacity in adolescents born extremely preterm/extremely low birth weight via maximal stress (maximal oxygen consumption) testing using a cycle ergometer and a metabolic cart. [Pre-testing, 10 week intervention, 10 week follow-up];Cardiopulmonary response to exercise in adolescents born extremely preterm/extremely low birth weight by estimating pulmonary pressure estimates via a trans-thoracic echocardiogram and exercising MRI. [Pre-testing, 10 week intervention, 10 week follow up.]