Erythropoietin Gel Effect on Dental Implant Stability

Not Applicable

Not yet recruiting

• Conditions: Osseointegration

• Registration Number: NCT06665451
• Lead Sponsor: Al-Azhar University

Brief Summary

* Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.

* The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.

* Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .

* The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study First Submitted: 2024-10-25
• Study First Submitted QC: 2024-10-29
• Last Update Submitted: 2024-10-29
• Study First Posted: 2024-10-30
• Last Update Posted: 2024-10-30
• Study Start: 2024-11
• Primary Completion: 2026-06
• Study Completion: 2026-07

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.
• Good general periodontal health and maintenance.

Exclusion Criteria

• Heavy smokers who smoke more than ten cigarettes per day
• Acute infected socket
• Ant socket with wall defect.
• Pregnency
• Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.
• Patients who had subjected to intravenous and/or oral bisphosphonate therapy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in implant stability	Baseline and after 6 month	Implant stability will be assessed by using ( AnyCheck - Implant Stability Tester ) Utilizes physical tapping technique and dumping capacity analysis to measure implant stability with precision

Secondary Outcome Measures

Name	Time	Method
Change in marginal bone level and bone density around implants	Baseline and after 6 month	To evaluate the amount of marginal bone loss and bone density around osseointegrated implants, all patient will be subjected to Cone beam computed tomography (CBCT) immediate postoperative and after 6 months.

Trial Locations

Locations (1)

Faculty of dental medicine Al-Azhar university; 🇪🇬 Assiut, Egypt