Resting Energy Expenditure of the COronaVirus (COVID19) Patient in Reanimation Context

Completed

• Conditions: COVID-19; Obesity
• Interventions: Diagnostic Test: indirect calorimetry

• Registration Number: NCT04391686
• Lead Sponsor: Centre Hospitalier Arras

Brief Summary

Compare the resting energy expenditure of COVID-19 patients (obese or non-obese) in intensive care unit with mechanical ventilation to a control group of non-COVID-19 intensive care patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-05-15
• Study First Submitted QC: 2020-05-15
• Study First Posted: 2020-05-18
• Study Start: 2020-07-03
• Primary Completion: 2021-11-04
• Study Completion: 2021-11-04
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-14
• Last Update Posted: 2022-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For the Ambulatory Obese Control Group, the inclusion criteria are:

• Age ≥ 18 years;
• Patient followed in the nutrition service;
• Patient who benefited from an indirect calorimetry whatever the indication between 01/01/20 and 31/12/2020;
• BMI> 30.

For the COVID Group and the Resuscitation Control Group, the inclusion criteria are:

• Age ≥ 18 years;
• Patient having undergone a resuscitation stay
• Patient on mechanical ventilation (intubated or tracheotomized) during their stay in intensive care;
• Patient having benefited from an indirect calorimetry upon arrival in intensive care;

Only for the COVID Group:

• Patient hospitalized in intensive care for COVID 19 infection diagnosed by a positive PCR via nasopharyngeal sampling or endotracheal aspiration.
• Patient who has not yet carried out his post-resuscitation visit;

Only for the Resuscitation Control Group:

• Patient hospitalized in intensive care for an indication other than an infectious cause.

Exclusion Criteria

Non-inclusion criteria for the Ambulatory Obese Control Group:

• Person deprived of liberty;
• Person subject to legal protection measures;
• Patient's opposition to participate in research.

The non-inclusion criteria for the COVID Group and the Resuscitation Control Group:

• For patients intubated during the resuscitation stay Fi02> 70% which does not allow a correct interpretation of the calorimetry;
• Pregnancy ;
• Person deprived of liberty;
• Person subject to legal protection measures;
• Opposition of the patient or the person of trust to participate in the research.

Only for the COVID Group:

• Contraindication to indirect calorimetry (claustrophobia for post-resuscitation patients where calorimetry is performed with a mask);
• Contraindication to bioimpedancemetry (electronic implants, limb amputation, weight <30kg or> 300kg);

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COVID intensive care unit	indirect calorimetry	-
obesity	indirect calorimetry	-
intensive care unit	indirect calorimetry	-

Primary Outcome Measures

Name	Time	Method
The resting energy expenditure (in Kcal / 24h) measured by indirect calorimetry during the stay in intensive care.	baseline and 3 months later

Trial Locations

Locations (1)

Arras general hospital; 🇫🇷 Arras, France