Fatty Acid Metabolism and Insulin Sensitivity After Exercise in Obesity

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Other: Exercise - caloric balance; Other: No Exercise - hyper-caloric diet; Other: No exercise - caloric balance

• Registration Number: NCT01451957
• Lead Sponsor: University of Michigan

Brief Summary

Alterations in fatty acid mobilization and oxidation may be primary adaptations responsible for the improvements in metabolic health after a single session of endurance exercise. The investigators will determine the effect of a single session of endurance exercise on whole-body fatty acid mobilization and oxidation, IMTG concentration and the expression of factors that regulate these processes in skeletal muscle of 11 women with abdominal obesity (age: 18-45y). In addition, the investigators will evaluate how these factors, and exercise, effect insulin signalling and insulin sensitivity. Every effort will be made to recruit subjects from ethnic and minority groups. Before participating in the study, subjects will be informed of all the procedures and potential risks, and they will sign an informed consent form approved by The University of Michigan Institutional Review Board. Eligible volunteers will participate in three separate trials, in a randomized order. In two trials subjects will eat exactly the same amount of calories, except in one trial they will exercise (eucaloric + exercise) and in the other trial they will remain sedentary (hypercaloric). In a third trial subjects will again remain sedentary but instead they will ingest appropriate calories to maintain caloric balance (eucaloric + sedentary). By doing this the investigators are also able to investigate the effect of acute caloric perturbations on insulin sensitivity, because it is possible that the enhanced insulin sensitivity evident after exercise, as compared to the sedentary state, is due to caloric deficit and not the exercise bout, per se.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2003-08
• Primary Completion: 2011-04
• Study Completion: 2011-04
• Study First Submitted: 2011-10-11
• Study First Submitted QC: 2011-10-13
• Study First Posted: 2011-10-14
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-22
• Last Update Posted: 2016-11-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 7

Inclusion Criteria

• Premenopausal; Body mass index 30-40 kg/m2; Waist circumference >88 cm

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Exclusion Criteria

• Evidence of metabolic or cardiovascular disease; Pregnancy; Hyperlipidemia (fasting plasma triglyceride concentration > 150 mg/dl); Hematocrit < 34%; Undertaking regular exercise (i.e., >2 times/week)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise - caloric balance	90 min exercise on Day 1
Sedentary Control	No Exercise - hyper-caloric diet	Subjects remain sedentary on Day 1 and will either consume a hyper-caloric or a caloric balanced diet
Sedentary Control	No exercise - caloric balance	Subjects remain sedentary on Day 1 and will either consume a hyper-caloric or a caloric balanced diet

Primary Outcome Measures

Name	Time	Method
Insulin Sensitivity	3 hours	frequently sampled intravenous glucose tolerance test(FSIVGTT)will be done to assess insuiln sensitivity

Trial Locations

Locations (1)

Michigan Clincal Research Unit; 🇺🇸 Ann Arbor, Michigan, United States