Transcranial magnetic stimulation (TMS) for patients with exposure therapy-resistant obsessive-compulsive disorder (OCD): TETRO - a multicenter randomized controlled trial - TETRO

Amsterdam UMC0 个研究点目标入组 250 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- OCD as current primary diagnosis
•- Age 18 and older
•- Yale-Brown Obsessive-Compulsive Scale (YBOCS) score of 16 or higher.
•- Insufficient response to state-of-the art exposure therapy with response
•prevention (ERP) and/or drop-out from ERP due to extreme anxiety/avoidance
•- The following comorbid disorders are allowed (as long as OCD is the current
•primary diagnosis): depression, other anxiety disorders, ADHD, tic/Tourette*s
•disorder, eating disorders, personality disorders, autism spectrum disorder
•(when this does not dominate the clinical profile, i.e. is not main diagnosis).
•- Commitment to actively undergo intensive exposure therapy (both supervised
•during ERP sessions, as well as unsupervised at home)
•- Unmedicated (for at least 8 weeks) or stable dosage of psychotropic
•medication (for at least 8 weeks), involving serotonergic antidepressants
•(SSRI, SNRI, clomipramine). Other psychotropic medication that is allowed
•(provided dosage is stably established for at least 8 weeks): methylphenidate,
•mood stabilizers, antipsychotic drugs
•- Ability to participate in frequent treatment sessions (4 days/week, for 5 (or
•6, or 7) weeks) at one of the 5 sites nearest to their home and/or work
•- Ability to participate in pre-treatment MRI session (for neuronavigation) at
•one of the 3 academic sites nearest to their home and/or work
•- Capacity for providing informed consent

•- OCD patients with hoarding as main symptom dimension
•- The following comorbid disorders (current diagnosis) are not allowed:
•psychotic disorders, bipolar disorder, autism spectrum disorder (when this
•dominates the clinical profile, i.e. is diagnosed as main disorder), substance
•use disorder
•- Active suicidal thoughts and intent to act on it
•- Chronic use of benzodiazepines is not allowed
•- Cochlear implant
•- (History of) epilepsy
•- Pregnancy
•- Extreme claustrophobia or metallic objects in or on the body, preventing from
•participation in MRI session
•- Space-occupying lesion on MRI
•- Previous rTMS treatment (for blinding reasons)

发起方

Amsterdam UMC