Pilot Study for Establishing Perioperative Tractography at Leipzig University Neurosurgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intracranial Neoplasm
- Sponsor
- Tim Wende
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Neurological Performance
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
In this pilot study participants will undergo routine magnetic resonance imaging and routine neurosurgical care. By prospectively collecting data from both MRI and patient records we want to investigate biomarkers derived from tractography and diffusion tensor imaging to predict rehabilitation potential.
Detailed Description
Patients will undergo MRI before and after surgery with DTI. With CSD-tractography, fiber bundles and their volumes will be identified. By measuring fractional anisotropy (FA) within these volumes, a correlation with clinical outcome and recovery will be tested. Also, FA frequency distributions will be used to describe white matter integrity and to thereby improve future tractography algorithms. Fiber bundles of interest will be the arcuate fascicle (AF), the corticospinal tract (CST), frontal aslant tract (FAT), the inferior fronto-occipital fascicle (IFOF), the inferior longitudinal fascicle (ILF) and the uncinate fascicle (UF).
Investigators
Tim Wende
MD
University of Leipzig
Eligibility Criteria
Inclusion Criteria
- •intracranial lesion
- •elective neurosurgical procedure
Exclusion Criteria
- •MRI not applicable
- •cerebral ischemia during study period
- •pregnancy during study period
- •encephalitis during study period
- •spontaneous intracerebral hemorrhage during study period
Outcomes
Primary Outcomes
Neurological Performance
Time Frame: three months
Neurological Performance Score (NPS)