Tractography Pilot Study Leipzig
- Conditions
- Intracranial Neoplasm
- Registration Number
- NCT04302857
- Lead Sponsor
- Tim Wende
- Brief Summary
In this pilot study participants will undergo routine magnetic resonance imaging and routine neurosurgical care. By prospectively collecting data from both MRI and patient records we want to investigate biomarkers derived from tractography and diffusion tensor imaging to predict rehabilitation potential.
- Detailed Description
Patients will undergo MRI before and after surgery with DTI. With CSD-tractography, fiber bundles and their volumes will be identified. By measuring fractional anisotropy (FA) within these volumes, a correlation with clinical outcome and recovery will be tested. Also, FA frequency distributions will be used to describe white matter integrity and to thereby improve future tractography algorithms. Fiber bundles of interest will be the arcuate fascicle (AF), the corticospinal tract (CST), frontal aslant tract (FAT), the inferior fronto-occipital fascicle (IFOF), the inferior longitudinal fascicle (ILF) and the uncinate fascicle (UF).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- intracranial lesion
- elective neurosurgical procedure
- MRI not applicable
- cerebral ischemia during study period
- pregnancy during study period
- encephalitis during study period
- spontaneous intracerebral hemorrhage during study period
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Neurological Performance three months Neurological Performance Score (NPS)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Leipzig University Hospital, Department of Neurosurgery
🇩🇪Leipzig, Sachsen, Germany