Evaluation of pulp response and mineralized tissue formation after direct pulp capping with calcium-silicate based cements

Phase 1

Active, not recruiting

• Conditions: Pulp exposureDirect pulp cappingDentin bridgeDentin bridge formationReparative dentin; Vital pulp therapy; Direct Pulp capping; Mineral Trioxide Aggregate; Biodentine; Dentin bridge formation; Reparative dentin

• Registration Number: TCTR20191103001
• Lead Sponsor: niversity of Medicine and Pharmacy at Ho Chi Minh city

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-11-03
• Study Completion: 2023-10-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1st or 2nd permanent premolars
Caries-free/ intact or small caries in enamel
Apex closed, no periapical changes (apical radiograph)
No periodontal pockets deeper than 4mm
Medical history non-contributory
No medication (no antibiotics during last month)
No signs or symptoms more severe than reversible pulpitis
Positive response to cold test or electrical pulp test
Written consent Inclusion requires compliance with all the criteria listed
patients willing to participate in study

Exclusion Criteria

Nonvital teeth
Open apex teeth
Pulp inflammation
Pulp necrosis
Root resorption
Periapical diseases
The bleeding of the exposed pulp cannot be controled in 10 minutes

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hard tissue bridge formation in CBCT 31/12/2023 Computer softwares

Secondary Outcome Measures

Name	Time	Method
Reparative dentin bridge formation in histologic sections 31/12/2023 Hematoxylin-eosin stain and immunochemistry stain