Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects
Completed
- Conditions
- DementiaAlzheimer Disease
- Interventions
- Other: Neuroimaging
- Registration Number
- NCT00951197
- Lead Sponsor
- University Hospital, Bordeaux
- Brief Summary
Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research. However, the research on AD progresses and some biomarkers have been recently suggested to improve the diagnostic criteria of AD, such as cerebrospinal fluid markers, neuroimaging with Positon Emission Tomography (PET) or Magnetic Resonance Imaging (MRI).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 318
Inclusion Criteria
- participate in the AMI cohort
- be aged 65 and older
- be retired from agricultural profession
- live in rural area in Gironde
Exclusion Criteria
- contraindication of MRI
- left-handed
- severe dementia
- Parkinson's disease
- poor health incompatible with the transport to neuroimaging service
- to be left handed
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description elderly subjects retired from agriculture Neuroimaging -
- Primary Outcome Measures
Name Time Method FA (Fractional Anisotropy), MTR (magnetization transfer ratio) and T2 (Transverse relaxation time) measures in patients with dementia compared to controls, in left and right hippocampus, and posterior cingulum day 0
- Secondary Outcome Measures
Name Time Method FA, MTR and T2 measures in subjects with mild cognitive impairment no dementia day 0 Performances in the 7 neuropsychological tests available in the AMI cohort day 0 FA measures for the connexion Hippocampus-cingulum posterior day 0
Trial Locations
- Locations (1)
Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux
🇫🇷Bordeaux, France