Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease

Not Applicable

Completed

• Conditions: Lung Cancer
• Interventions: Procedure: chest computed tomography scan

• Registration Number: NCT00601146
• Lead Sponsor: Dana-Farber Cancer Institute

Brief Summary

This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.

Detailed Description

- Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.

Study Timeline

• Study Start: 2006-11-01
• Study First Submitted: 2008-01-15
• Study First Submitted QC: 2008-01-15
• Study First Posted: 2008-01-25
• Primary Completion: 2010-12-01
• Results First Submitted: 2016-01-19
• Results First Submitted QC: 2016-01-19
• Results First Posted: 2016-02-17
• Study Completion: 2019-12-01
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-09
• Last Update Posted: 2020-01-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• 5 years or longer from initial Hodgkin's disease diagnosis
• Current age 18 or older
• Received mediastinal irradiation and/or alkylating-agent based chemotherapy
• Smoking history of 10-pack years or more, or current smoker
• Pre-approval from the participant's insurance company for the CT study

Read More

Exclusion Criteria

• Patients with a history of lung cancer
• Currently receiving treatment for another cancer diagnosis
• Known diagnosis of any metastatic cancer
• Pregnant women

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Low-dose Chest CT screening	chest computed tomography scan	Annual low-dose Chest CT screening

Primary Outcome Measures

Name	Time	Method
To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease.	3 years	In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded

Trial Locations

Locations (2)

Brigham and Women's Hospital; 🇺🇸 Boston, Massachusetts, United States

Dana-Farber Cancer Institute; 🇺🇸 Boston, Massachusetts, United States