IRCT20170426033658N2
Completed
Phase 2
Comparison of the effect of oral immunotherapy with cow's milk products and conventional desensitization in children with allergy to heated cow's milk: a clinical trial
Vice chancellor for Research of Tehran University of Medical Sciences0 sites25 target enrollmentTBD
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Vice chancellor for Research of Tehran University of Medical Sciences
- Enrollment
- 25
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients two years and older
- •Presentation of skin symptoms such as urticaria, erythema and angioedema
- •gastrointestinal symptoms such as severe vomiting, abdominal pain and diarrhea
- •respiratory symptoms such as rhinitis and bronchospasm
- •Presentation of the symptoms up to two hours after exposure
- •these symptoms should be present at least in last six months
- •positive skin prick test for cow's milk or measurement of sIgE for cow's milk
- •positive challenge test with cow's milk
Exclusion Criteria
- •cellular immune response that is not mediated by IgE
- •malignancy or severe immunodeficiency disorders
- •using beta blockers
- •uncontrolled severe persistent asthma
- •Cardiovascular disease that epinephrine administration is contraindicated in them
- •Taking immunosuppressive drugs
- •previously diagnosed Eosinophilic Gastrointestinal Disorder in response to milk
Outcomes
Primary Outcomes
Not specified
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