The effect of lowering salt intake on ambulatory blood pressure and cardiovascular risk in patients with chronic kidney disease

Phase 1

Completed

• Conditions: Cardiovascular risk factors; Chronic Kidney Disease; Renal and Urogenital - Kidney disease; Cardiovascular - Hypertension; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12611001097932
• Lead Sponsor: Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-10-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

CKD stage 3 or 4 (GFR 15-59 ml/min/1.73m2) patients under the care of a nephrologist at the Princess Alexandra Hospital
- Aged at least 18 years
- Able to provide informed consent
- Systolic BP 130-169 mmHg
- Diastolic BP >70 mmHg.

Exclusion Criteria

- Unable or unwilling to attend the PAH for visits as specified by the study protocol
- Receiving renal replacement therapy (dialysis or transplant) or likely to within the trial duration
- Salt-wasting CKD (as diagnosed by nephrologist)
- Prescribed > 1680 mg of sodium bicarbonate and not able to cease this medication for six weeks
- Pregnant or breastfeeding
- Life expectancy less than 6 months.
- Current involvement in other intervention
- Unable to comprehend study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in 24hr Ambulatory Blood Pressure (mm hg) assessed using ambulatory blood pressure monitor (TM-2430 Ambulatory Blood Pressure Monitor, A & D Medical, Australia).[Ambulatory blood pressure will be measured at baseline (Visit 0), at the end of each of the two 2 week interventions (Visit 3 and 6), and at 4 months and 6 months (Visit 7 and 8). Measurements will be taken over 24 hours every 20 minutes from 6am to 10pm and every 30 minutes from 10pm to 6am.]