Efficacy of Gadolinium Contrast in CT Pulmonary Angiography in Patients With Allergy to Iodine
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Diagnosis of Pulmonary Embolism
研究概览
简要总结
The study will investigate patients with clinical suspicion for pulmonary embolism (PE) who have a contraindication to iodine based contrast. These patients normally get investigated with studies such as ultrasound and nuclear medicine studies but the fastest and preferred investigation is CT with contrast to look for filling defects in the pulmonary arteries. The investigators will assess whether gadolinium, which is currently used with MRI can be used with CT as an alternative effective contrast in diagnosis or exclusion of PE. A new type of CT scanner, a Dual Energy Scanner will be used to improve the visibility of Gadolinium contrast on CT.
详细描述
Contrast enhancement with Gadolinium will be evaluated to assess its efficacy for diagnosis and exclusion of pulmonary embolism in a patient who previously would not have been investigated with CTPA due to an underlying allergy to contrast or other contraindication. If this proves beneficial, it will allow such patients to be investigated successfully with CTPA
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients suspected of having a Pulmonary embolus
- •Allergy to Iodine based intravenous contrast
排除标准
- •Renal impairment
- •Less than 20 years of age
- •Non-English speaking
- •Pregnancy
- •Allergy to Gadolinium
研究组 & 干预措施
Gadolinium enhancement
Gadolinium enhancement will be performed using intravenous Dotarem[recommended dose of 0.2 mL/kg (0.1 mmol Gd/kg )]
干预措施: Gadolinium (Drug)
结局指标
主要结局
Diagnosis of Pulmonary Embolism
时间窗: 24 hours
Ability of Gadolinium to diagnose pulmonary embolism on a dual energy CT scan
次要结局
未报告次要终点
研究者
Amita Sharma, MD
Radiologist
Massachusetts General Hospital