Comparative Study Between Platelet Rich Plasma and Steroid Injection in Trigger Finger Treatment

Phase 3

Not yet recruiting

• Conditions: Trigger Finger Disorder
• Interventions: Drug: Pfizer Depo-medrol; Biological: Platelet rich plasma

• Registration Number: NCT06532318
• Lead Sponsor: Obafemi Awolowo University Teaching Hospital

Brief Summary

The goal of this clinical trial is to learn if platelet rich plasma works to treat early stage trigger finger in adults. It will also learn about the safety platelet rich plasma. The main questions it aims to answer are:

Does platelet rich plasma lower the pain associated with trigger finger of participants? Does it improve the hand grip strength and Q DASH score of participants? Researchers will compare platelet rich plasma to Depo-Medrol steroid (a known standard of care for early stage trigger finger) to see if platelet rich plasma works to treat early trigger finger.

Participants will:

Take platelet rich plasma or a depo-medrol steroid intralesional injection at recruitment into the intervention Visit the clinic once every 4 weeks for checkups and parameter measurements. Investigator will will keep a record of participants progress in symptom remission

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-07
• Study Start: 2024-07-24
• Study First Submitted: 2024-07-29
• Study First Submitted QC: 2024-07-31
• Last Update Submitted: 2024-07-31
• Study First Posted: 2024-08-01
• Last Update Posted: 2024-08-01
• Primary Completion: 2024-12-23
• Study Completion: 2025-06-23

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients who are 18year and above with mild or moderate trigger finger, who are willing to have intra-lesional administration of blood product.

No previous treatment for the affected finger.

Exclusion Criteria

• Previous steroid injection
• Previous Surgery to that finger
• Thrombocytopenic patients
• Hand and finger contracture
• Rheumatoid arthritis of the finger

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Group B	Pfizer Depo-medrol	Patients here will have one milliliter(20mg) injection of pfizer Depo-medrol(methylprednisolone acetate) injection for the treatment of their trigger finger.
Group A	Platelet rich plasma	Patients here will have one milliliter of freshly prepared autologus platelet rich plasma injection for the treatment of their trigger finger.

Primary Outcome Measures

Name	Time	Method
symptom resolution post injection	3 months	reduction of pain using VAS and absence snapping of finger

Secondary Outcome Measures

Name	Time	Method
Hand grip strength	3 month	measured grip using hand dynamomter
Q- DASH score	3month	11-item self reported disability questionnaire that consider upper extremity as one functional unit