Effectiveness of Peer Navigation and Contingency Management on Retention in HIV Care

Not Applicable

Completed

• Conditions: HIV/AIDS

• Registration Number: NCT02310893
• Lead Sponsor: University of California, Los Angeles

Brief Summary

Consistent treatment with anti-retroviral therapy (ART) suppresses viral load (VL), prolonging life and improving quality of life for HIV+ persons. Suppressing VL benefits communities by reducing transmission to others. Mere availability of ART and care, however, is insufficient; the benefits of ART depend upon HIV+ persons' continuous visits to the health care provider, regular monitoring and regular delivery of medications, - known as retention in HIV care. In spite of national efforts, up to a quarter of HIV+ persons, especially low-income minorities are out of care. Innovative interventions are therefore urgently needed to maximize engagement and retention in HIV care, self-reported adherence, as well as HIV-1 RNA viral load suppression. In pursuit of these aims, the proposed study will assess outcomes of the following interventions in comparison to usual care: 1) contingency management (CM) only; 2) peer navigation (PN) only; and 3) a combined approach that integrates both CM and PN (CA) which the investigators hypothesize to be most effective in improving HIV clinical outcomes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-07-18
• Study First Submitted QC: 2014-12-04
• Study First Posted: 2014-12-08
• Study Start: 2016-01
• Primary Completion: 2019-12
• Study Completion: 2020-01
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-16
• Last Update Posted: 2020-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 579

Inclusion Criteria

1. Diagnosed HIV+
2. Age 18 years or older
3. English or Spanish speaking
4. Residence in Los Angeles County
5. prescribed ART in prior 24 months
6. < 3 visits in prior 12 months or have detectable viral load, as identified in the Ryan White CaseWatch database

Exclusion Criteria

Not meeting any of the criteria identified above

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Change in HIV RNA viral load suppression and medication adherence over 12 months	Basline, follow-ups at month 2, and 12	Using the same design, to examine the effects of the PN, CM and, CA interventions on HIV RNA viral load suppression and self-reported adherence
Change in retention-in-care behaviors over 12 months	Basline, follow-ups at month 2, 6, 12	Using a 2x2 factorial design, to examine the effect of the three interventions -- peer navigation, contingency management, combined approach and usual care -- and evaluate how well they improve retention in HIV care

Secondary Outcome Measures

Name	Time	Method
Cost effectiveness	5 years	A secondary aim is to examine the cost-offset and potential cost-effectiveness of each intervention compared with usual care

Trial Locations

Locations (6)

Center for Health Justice; 🇺🇸 Los Angeles, California, United States

Los Angeles Sheriff's Department; 🇺🇸 Los Angeles, California, United States

AltaMed Health Services Corporation; 🇺🇸 Los Angeles, California, United States

Oasis Clinic; 🇺🇸 Los Angeles, California, United States

Olive View Medical Center; 🇺🇸 Sylmar, California, United States

Northeast Valley Health Corporation; 🇺🇸 Van Nuys, California, United States