The search for biomarkers to enable detection and monitoring of disease progression from NAFLD to NASH and NASH itself; the Amsterdam NASH cohort
- Conditions
- AFLD, NASH
- Registration Number
- NL-OMON19935
- Lead Sponsor
- Academic Medical Center (AMC), Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 1100
Inclusion Criteria
•Diagnosis of steatosis hepatis on ultrasound or by biopsy
•>18 years of age
Exclusion Criteria
•Abusive alcohol use (>20 IU/week)
•Hepatitis B and/or C
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to identify and validate noninvasive diagnostic methods (imaging and molecular markers) in disease progression from NAFLD to NASH as well as progression of NASH itself
- Secondary Outcome Measures
Name Time Method to apply a systems biology approach to identify the hierarchy of driving mechanisms (microbial and metabolic markers) involved in the conversion of NAFLD-NASH and NASH-cirrhosis after 5 years