Validation of the German Short Version of the Autobiographical Memory Interview in Patients With Depression and Healthy Controls
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- German Autobiographical Memory Interview short-form
研究概览
简要总结
Electroconvulsive therapy (ECT) is recommended for the treatment of severe depression. But, despite the high remission rates the use of ECT is strongly limited by the social stigma and treatment-emergent cognitive side effects in patients. The most relevant is retrograde amnesia (RA), because it can persists for months and years. To measure RA after ECT the short-form of the Autobiographical Memory Interview (SF-AMI) is commonly used. However, the validation of the German SF-AMI has not yet been carried out. Thus, the aim of this study is to validate the German SF-AMI in depressed patient and healthy controls.
The investigators hypothesize that the German SF-AMI is reliable and valid to quantify RA.
详细描述
To measure retrograde amnesia of autobiographical memory after ECT, various tests were used so far. Currently, the short form of the Autobiographical Memory Interview (AMI-SF) was used most frequently internationally. In Germany there is no validated translation of the AMI-SF. However, in order to be able to systematically record the cognitive side effects of ECT in clinical practice as well as in research in the German-speaking area, it is important to have validated test procedures that can be successfully used in repeated measurements. In this study, the German version of the AMI (D-AMI), i.e. the specificity of the German short version of the autobiographical memory in patients with depression will be investigated. It is also known in healthy people that autobiographical memory contents can no longer be called up over time. Therefore, the aim of this study is to investigate whether a change in autobiographical memory over the course of time in depressed patients differs from healthy control subjects. It should also be shown whether this German short version for examining autobiographical memory (D-AMI) can be carried out.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •HDRS > 17
- •Age 18-80
- •Ability to give informed consent
排除标准
- •Drugs or drug abuse or addictions
- •Use of benzodiazepine equivalent to lorazepam> 1.5 mg per day
- •Cognitive impairments
- •History of traumatic brain injury
- •Relevant organic disease, e.g. Multiple sclerosis, Parkinson's disease
- •Bipolar illness, dementia or schizophrenic disorder
- •German is not the mother tongue
- •Inability to give informed consent
研究组 & 干预措施
Patients with depression
- Major depression according to DSM-V and ICD-10 (ICD F32.1, F32.2, F32.3, F33.1, F33.2, F33.3)
- Hamilton Depression Rating Scale > 17
干预措施: German Autobiographical Memory Interview short-form (Diagnostic Test)
Healthy controls
- Mental health
干预措施: German Autobiographical Memory Interview short-form (Diagnostic Test)
结局指标
主要结局
German Autobiographical Memory Interview short-form
时间窗: pre-post (six weeks)
Changes in autobiographical memory measured with the German Autobiographical Memory Interview short-form pre-post in depressed patients vs. a healthy control Group.
次要结局
- Hamilton Depression Rating Scale (HAMD-17)(pre-post (six weeks))
- Inventar Depressiver Symptome (IDS)(pre-post (six weeks))
- Global Self-Evaluation-Memory (GSE-My)(pre-post (six weeks))
- 36-item Health Survey (SF-36)(pre-post (six weeks))
研究者
Sarah Kayser
PD Dr. med. Sarah Kayser, MSc.
Rheinhessen-Fachklinik Alzey