Cohort Study of Chronic Heart Failure

Recruiting

• Conditions: Heart Failure

• Registration Number: NCT05960890
• Lead Sponsor: Jiangsu Taizhou People's Hospital

Brief Summary

The goal of this observational study is to learn about the influencing factors of chronic heart failure prognosis in heart failure patients. The main question it aims to answer is that what are the influencing factors of clinical outcomes in chronic heart failure. Participants will be collected multiple omics data such as phenotype group, environmental exposure group, intestinal microbiome, genome, metabolome, and noninvasive biomarkers.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-08
• Status Verified: 2023-07
• Study First Submitted: 2023-07-07
• Study First Submitted QC: 2023-07-23
• Last Update Submitted: 2023-07-23
• Study First Posted: 2023-07-27
• Last Update Posted: 2023-07-27
• Primary Completion: 2025-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

1. Over 18 years old
2. Dilated cardiomyopathy, hypertensive cardiomyopathy, ischemic cardiomyopathy (coronary heart disease), non-severe valvular heart disease
3. LVEF<50%, and/or NT-proBNP>1800ng/L, and/or BNP>100ng/L, NYHA I-III grade
4. Able to understand and sign informed consent forms

Exclusion Criteria

1. Expected life less than 3 months
2. Patients with severe renal insufficiency (Ccr<30ml/min) or undergoing dialysis treatment
3. Cardiac insufficiency caused by various secondary causes that can be corrected includes hyperthyroid heart disease, anemic heart disease, and uncorrected Congenital heart defect
4. Presence of indications for pacemaker implantation and absence of pacemaker implantation
5. Chronic obstructive pulmonary disease with type II Respiratory failure
6. Special populations such as mental illness patients and pregnant women
7. Unable to understand and sign informed consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite endpoint of cardiovascular death and rehospitalization for heart failure	2 years	Cardiovascular disease death and heart failure readmission are two endpoint events, with either occurring as the primary endpoint

Secondary Outcome Measures

Name	Time	Method
all-cause mortality	2 years	all-cause mortality

Trial Locations

Locations (1)

Taizhou People's Hospital affiliated to Nanjing Medical University; 🇨🇳 Taizhou, Jiangsu, China