The Pancreatic Adenocarcinoma Gene Environment Risk Study -A Prospective Cohort Study of Patients at Risk or Having Pancreatic Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- The data will be used in cohort association studies. Endpoints will depend on the number of patients in the study and the number of markers that are being evaluated.
研究概览
简要总结
After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Some participants may also be asked to provide a urine sample. Individuals undergoing procedures that require collection of biological samples for clinical purposes may have these samples saved for research purposes. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Histologically confirmed or CT confirmed diagnosis of pancreatic adenocarcinoma
- •Subjects with abnormal imaging study (CT, MRI, MRCP, EUS)
- •Control subjects with a clinical diagnosis of a pancreas, liver, or intestinal condition
- •Control subject with acute pancreatitis
- •Control subject with chronic pancreatitis
- •Control subject with biliary obstruction
- •Control subject with pancreatic cyst
- •Member of a high risk family (≥ 1 close relative with pancreatic cancer)
- •Healthy control (without any of the above conditions)
排除标准
- •Under the age of 18 years
- •Unable to give informed consent
- •Inability to travel to Pittsburgh for in-person enrollment
结局指标
主要结局
The data will be used in cohort association studies. Endpoints will depend on the number of patients in the study and the number of markers that are being evaluated.
时间窗: 10 years
次要结局
未报告次要终点
研究者
Randall Brand
M.D.
University of Pittsburgh