NCT05118646Unknown不适用
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Early Fluid Resuscitation in Patients With Septic Shock
Xiangya Hospital of Central South University1 个研究点 分布在 1 个国家目标入组 62 人开始时间: 2020年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- change in SOFA score
研究概览
简要总结
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
详细描述
Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock.
Intervention:
- Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV > 68%).
- Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.
Primary outcome:
(1)change in SOFA score at 72h (2)30-day mortality
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients fulfilled the diagnostic criteria of septic shock.
排除标准
- •declined to participate
- •patients who were younger than 18 years old
- •active bleeding
- •septic shock is diagnosed for more than 4 hours
- •patients are expected to be die within 24hours
结局指标
主要结局
change in SOFA score
时间窗: 72h
△SOFA
次要结局
- 30-day mortality(30d)
研究者
研究点 (1)
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