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临床试验/CTRI/2023/03/051056
CTRI/2023/03/051056尚未招募2 期

AÂ Comparative Study to Evaluate the Efficacy of Kantakari Ksheera seka And Paya Saindhava Seka in The Management of Shushkakshipaaka

Dr Mohan dudwe1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2023年3月29日最近更新:
适应症

试验速览

阶段
2 期
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
schirmers test

研究概览

简要总结

Sushkakshipaka is one of the Vataja(Sushruta)1 /Vata-pittaja(Vagbhata) Sarvagata, Sadhya Netrarogas. Features of Shushkakshipaka includes hard and dry eye lids, found drooping; blurred vision and difficulty to open the eyes with foreign body sensation2 . The Lakshanas of Shushkakshipaka can be equated with the signs and symptoms of Dry Eye Syndrome. Dry Eye is a disorder of the tear film due to tear deficiency or excessive tear evaporation which causes damage to the inter palpebral ocular surface and is associated with symptoms of ocular discomfort. The climate of tropical India and globalization along with the sprout of millions of IT professionals are making Dry Eye Syndrome, a fast growing disease, as all these leads to increased tear evaporation (due to dry wind, air conditioning, decreased blink reflex etc.) along with other causes like aqueous tear deficiency, mucin deficiency, lipid deficiency, impaired lid function, irregular corneal surface etc.The prevalence of DES in India is higher than the global prevalence and ranges from 18.4% to 54.3%. To explore effective solution in Ayurveda is the need of the hour as is no complete cure for Dry eyes in contemporary medicines at present.Some of the treatment modalities which have been tried with variable results include supplementation with tear substitutes, topical cyclosporine, mucolytic, topical retinoid, preservation of existing tears etc. along with correction of lid abnormalities, which are not long lasting and thus long-term usage is recommended. The treatment modalities that are told in classics for this are Ghritapaana, Tarpana, Seka, Aschotana, Anjana etc. which are known to increase the stability of tear film and give relief from the symptoms of Shushkakshipaka.  Hence this study is taken to overcome the challenges in treating the dry eye syndrome.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant Blinded

入排标准

年龄范围
20.00 Year(s) 至 50.00 Year(s)(—)
性别
All

入选标准

  • •all the patients presenting with signs and symptoms of Sushkakshipaka irrespective of gender, caste, religion, socio-economic status and chronicity.

排除标准

  • •1.Injuries(Mechanical/chemical)-Abhighataja netra roga 2.Systemic disorders like Rheumatoid arthritis, SLE and Sjögren’s Syndrome 3.Patients who are using drugs like antihistamines, decongestants, hormonal therapy, antidepressants, dermatologic medications, antipsychotic medications and chemotherapy medications 4.Congenital Alacrima 5.Associated with any inflammatory and infective ocular conditions and other conditions like glaucoma.

结局指标

主要结局

schirmers test

时间窗: 51 days

Tearfilm Break Up Time

时间窗: 51 days

次要结局

  • Assessed using self generated scoring(1.Gharsha)

研究者

发起方
Dr Mohan dudwe
申办方类型
Other [self]

研究点 (1)

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