Artificial Intelligence-Based Analysis of Uroflowmetry Patterns in Children: a Machine Learning Perspective

Completed

• Conditions: Voiding Dysfunction; Voiding Disorders; Machine Learning

• Registration Number: NCT06814847
• Lead Sponsor: Marmara University

Brief Summary

Uroflowmetry is the one of the most commonly used non-invasive test for evaluating children with lower urinary tract symptoms (LUTS). However, studies have highlighted a weak agreement among experts in interpreting uroflowmetry patterns. This study aims to assess the impact of machine learning models, which have become increasingly prevalent in medicine, on the interpretation of uroflowmetry patterns.

Detailed Description

The study included uroflowmetry tests of children aged 4-17 years who were referred to our clinic with lower urinary tract symptoms. Uroflowmetry patterns were independently interpreted by three pediatric urology experts. Discrepancies in interpretations were jointly re-evaluated by the three observers, and a consensus was reached. Voiding volume, voiding duration, and urine flow rates at 0.5-second intervals were converted into numerical data for analysis. Eighty percent of the dataset was used as training data for machine learning, while there maining 20% was reserved for testing. A total of five different machine learning models were employed for classification: Decision Tree, Random Forest, CatBoost, XGBoost, and LightGBM. The models that most accurately identified each uroflowmetry pattern were determined.

Study Timeline

• Study Start: 2024-10-01
• Primary Completion: 2025-01-01
• Status Verified: 2025-02
• Study Completion: 2025-02-01
• Study First Submitted: 2025-02-03
• Study First Submitted QC: 2025-02-03
• Study First Posted: 2025-02-07
• Last Update Submitted: 2025-02-22
• Last Update Posted: 2025-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Aged between 4 and 17 years with LUTS
• Urinate more than 50% of the expected bladder capacity on UF

Exclusion Criteria

• Patients who were unable to cooperate with the voiding command
• Had neurological disorders
• Urinate less than 50% of the expected bladder capacity on UF
• Under 4 years of age, and were over 18 years of age

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Performance of Machine Learning Models in Evaluating Voiding Patterns	From October 2024 to January 2025	5 different machine learning models were used. Accuracy rates were determined for each model.

Trial Locations

Locations (1)

Marmara University School of Medicine, Urology Department; 🇹🇷 Istanbul, Turkey