Clinical Phase II Clinical Study Evaluating the Toxicity and Efficacy of mFOLFIRINOX Associated With SBRT (Stereotactic Radiotherapy) in Patients With Unresectable Locally Advanced Pancreatic Cancer
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Improvement of the overall survival.
研究概览
简要总结
Primary goal:
Improvement of the therapeutic index by reducing the toxicity of treatment and increasing local control of the cancer process while evaluating the possibility of conversion to the surgical status.
Secondary targets:
- Survival rate (OS) assessment in patients treated with mFOLFIRINOX + SBRT
- Assessment of quality of life using questionnaires: EQ-5D, EORTC (QLQ-C30) and pancreatic cancer-specific QLQ PAS module 26
- Early toxicity <3 months after completion of SBRT treatment.
- Percentage of local control (1-year)
详细描述
STUDY PLAN Patients will receive initial mFOLFIRINOX (6 cycles) chemotherapy, followed by evaluation of the response to the treatment (imaging and laboratory testing) followed by SBRT, followed by mFOLFIRINOX chemotherapy.
In case of exclusion of disease progression after 10 weeks +/- 2 weeks after completion of SBRT, patients will be qualified to surgical treatment to attempt a radical surgical treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signing informed consent for treatment.
- •Age> = 18 years.
- •Patients with histopathological diagnosis of adenocarcinoma of the pancreas.
- •Advanced disease referred to as locally advanced definitive non-resetable, non-metastatic pancreatic cancer.
- •No prior systemic treatment due to pancreatic adenocarcinoma
- •No prior radiotherapy in the abdominal area
- •No prior radical surgical treatment due to pancreatic adenocarcinoma (palliative surgical procedures such as bypass surgery or biliary tract surgery are acceptable).
- •Expected survival time in excess of 12 weeks.
- •Adequate organ performance based on laboratory blood tests.
排除标准
- •Patients diagnosed with other types of pancreatic cancer than adenocarcinomas (eg neuroendocrine cancer).
- •Advanced disease that allows primary surgical treatment.
- •Borderline pancreatic cancer (BRPC) disease.
- •The presence of metastases.
- •Previous systemic treatment because of pancreatic adenocarcinoma.
- •Preoperative radiotherapy in the abdominal area.
- •Previous radical surgery for pancreatic adenocarcinoma.
- •Large surgical procedure with the exception of diagnostic biopsies within the last 4 weeks after the start of treatment and / or patients who have not fully recovered after surgery.
- •Heart failure (NYHA Class II, III or IV)
- •Hemodynamic instability in the course of coronary and / or valvular heart disease and / or hypertension and / or other clinical conditions (eg uncontrolled diabetes mellitus).
- •Clinically relevant cardiac arrhythmias requiring treatment.
- •Stroke and / or myocardial infarction history within 6 months of inclusion.
- •Respiratory failure associated with other co-morbidities.
- •Serious psychiatric illnesses, which, in the researcher's opinion, could have a significant negative impact on the safety of the treatment.
- •Other serious accompanying illnesses, which, in the researcher's opinion, could seriously adversely affect the safety of the treatment.
- •Transplanted organ transplant including allogeneic bone marrow transplant.
- •Positive diagnosis for HBV or HCV indicating acute or chronic infection (for screening).
- •HIV infection.
- •The period of pregnancy and breastfeeding.
- •Alcoholism or drug abuse.
- •Limited legal capacity.
研究组 & 干预措施
Arm 1
干预措施: Patients will receive initial chemotherapy, followed by evaluation of the response to the treatment, followed by SBRT, followed by chemotherapy. (Drug)
结局指标
主要结局
Improvement of the overall survival.
时间窗: 60 months.
Improvement of the overall survival by new treatment method.
Improvement of the therapeutic index.
时间窗: 24 months.
Improvement of the therapeutic index by reducing the toxicity of treatment and increasing local control of the cancer process while evaluating the possibility of conversion to the surgical status.
次要结局
未报告次要终点
研究者
Katarzyna Kuśnierz
Investigator
Medical University of Silesia