Effectiveness of improved diet for children with moderate acute malnutritio

Not Applicable

Completed

• Conditions: Malnutrition; Children with moderate acute malnutrition; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN42569496
• Lead Sponsor: niversity of Copenhagen (Denmark)

Brief Summary

2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26739038 observational study results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28705254 polyunsaturated fatty acid results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28892496 fat-free tissue accretion results 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30143567 fat accumulation results (added 16/05/2019) 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26752599 acceptability results (added 23/12/2019) 2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/27910283 feeding behaviors results (added 23/12/2019) 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29529160 hemoglobin, iron status, and inflammation results (added 23/12/2019) 2016 Results article in https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-016-0096-0 inflammation results (added 23/12/2019) 2017 Results article in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282395/ physical activity results (added 23/12/2019) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32764545/ admission criteria and body composition results (added 10/08/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33362221/ child development results (added 29/12/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33963730/ (added 10/05/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35263343/ Serum cobalamin secondary analysis results (added 10/03/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-08-02
• Study Completion: 2014-09-01
• Last Update Posted: 21 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1609

Inclusion Criteria

1. Weight-for-height z-score (WHZ) = -3 and < -2 (based on the WHO growth standard) or Mid Upper Arm Circumference (MUAC) =115mm and < 125 mm
2. 6 to 23 months of age
3. Resident in the catchment area at the time of inclusion
4. Whose parents/guardians have signed (or thumb-printed whenever illiterate) the informed consent

Exclusion Criteria

1. Children with severe acute malnutrition defined as a WHZ < -3, and/or a MUAC <115 mm, and/or bilateral pitting oedema.
2. Children with medical complications requiring hospitalization
3. Children whose household plans to leave the catchment area in the next 6 months
4. Children with a hemoglobin concentration <4g/dl or with evidence of a decompensate anemia (e.g. dyspnea, tachycardia etc)
5. Children who have been treated for SAM or who have been hospitalized in the last 2 months
6. Children with known allergy to milk, peanut, corn soya blend (CSB) and/or ready to use therapeutic food (RUTF)
7. Children with a severe disability limiting the possibility of investigations
8. Children enrolled in any other nutritional program or part of any other study conducted in the area

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Absolute lean mass increment from baseline to 3 months measured using the deuterium dilution method