ADHD, from behaviour to biology

Completed

Conditions: ADHD
Attention Deficit Hyperactivity Disorder
10012562

Registration Number: NL-OMON39334

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 450

Inclusion Criteria

Inclusion criteria for parents:
• No additional criteria if a child meets all of the inclusion criteria;General inclusion criteria for all subject groups (excluding parents):
• Aged 6 through 18 years at first scan
• Ability to speak and comprehend Dutch;Inclusion criteria for subjects with ADHD
• Clinical DSM-IV diagnosis of ADHD, supported by the Diagnostic Interview Schedule for Children (DISC) ;Inclusion criteria for control subjects
• No DSM-IV diagnosis, according to the DISC
• No scores in the clinical range on any scale of the Child Behavior Checklist (CBCL) as reported by one of the parents.;Inclusion criteria for subjects with a psychiatric diagnosis but no diagnosis of ADHD
• Any clinical DSM-IV diagnosis except ADHD, supported by the DISC interview
• A score in the subclinical or clinical range of the CBCL subscale of Attention Problems as reported by one of the parents.

Exclusion Criteria

Mental retardation (IQ < 70)
Major illness of the cardiovascular, endocrine, pulmonal or the gastrointestinal system
Presence of interfering metal objects in or around the body (eg. pacemaker)
History of or present neurological disorder. A neurological disorder is defined as any disorder that requires care from a neurologist.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/endpoint<br /><br>(1) Task related brain activity (BOLD-signal change) and connectivity measures<br /><br>from fMRI<br /><br>(2) Neuropsychological performance measures collected with computerized tasks<br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters/endpoints<br /><br>(1) Resting-state functional connectivity, assessed with resting-state fMRI<br /><br>(2) Symptoms of ADHD from symptom rating scales (CBCL/TRF/SWAN)<br /><br>(3) White matter integrity, assessed using tract-based FA (Fractional<br /><br>Anisotropy) measures from DTI (Diffusion Tensor Imaging)<br /><br>(4) Genotype on risk genes for ADHD </p><br>