IVA

Not Applicable

Conditions: Health Condition 1: J980- Diseases of bronchus, not elsewhere classified

Registration Number: CTRI/2019/05/019079

Lead Sponsor: ONE

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

CHILDREN PRESENTING TO THE PEDIATRICS EMERGENCY OR OUT PATIENT DEPARTMENT WITH ACUTE EXACERBATION DEFINED AS TACHYPNEA,HISTORY OF PREVIOUS SIMILAR EPISODES AND WHEEZING

Exclusion Criteria

1.Children presenting with respiratory failure requiring immediate endotracheal intubation and assisted ventilation

2.Children with physician diagnosed bronchiolitis defined as the coryzal prodrome lasting 1 to 3 days followed by the persistence of cough and either tachypnea/chest recession and either wheeze/crackles on auscultation

3.Clinical suspicion of bacterial pneumonia:focal crackles or bronchial breathing and/or major chest x ray finding [consolidation,major infiltrates,pleural effusion]

4.Any contraindication to NIV use including altered mental status, recent bowel surgery,intractable vomiting,inability to protect airway

5.Current tracheostomy,home ventilation[IPPV or NIPPV]or home oxygen requirement

6.Receiving maintenance dose of oral steroid at time of hospital admission

7.History of congenital heart disease or chronic heart disease [including bronchopulmonary dysplasia,cystic fibrosis,pulmonary hypertension]

8.Craniofacial abnormality

9.pneumothorax at present

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ength of the time to reach pram score less than 3Timepoint: Assessment every hourly till pram score is less then 3

Secondary Outcome Measures

Name	Time	Method
1.Length of time to achieve hospital discharge criteria <br/ ><br>2.Time to room air respiration <br/ ><br>3.Comparison of bronchodilator requirement between groups [ median number of intravenous infusion hours,total salbutamol doses per patient per admission ,median doses of salbutamol per day] <br/ ><br>4.Each group that require intubation and invasive ventilation <br/ ><br>5.Each group experiencing significant treatment related side effects <br/ ><br>6.Each group requiring hospital readmission within 48 hours of dischargeTimepoint: Assessment every hourly