CTIS2022-500366-10-00招募中1 期
Effect of orlistat on LIVER fat content in obese subjects with NAFLD and High concEntrAtion of pLasma proneurotensin THrough inhibition of neurotensin secretion and action
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- Region Skane
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •*Age 20-65 years, *Written informed consent, *Negative pregnancy test in women of child bearing potential (WOCBP), *Body mass index =30kg/m2, *plasma concentration of pro-NTS>150 pmol/L, *LFC% >5.6% in the absence of other causes of steatosis than NAFLD
排除标准
- •*Allergy or hypersensitivity of orlistat, *Hypothyroidism, *Hepatitis C, *Epilepsy, *Concomitant medication with any of the following: any oral anticoagulants, any anti-epileptic medications, ciclosporin, corticosteroids, diltiazem, amiodarone, antiviral HIV therapy, levothyroxine, and acarbose, *Estimated glomerular filtration rate <30 mL/min, *Claustrophobia, *Implants contraindicating magnetic resonance imaging such as pacemaker, metallic clips in blood vessels or brain and cochlea implant, *Alcohol intake >20g per day, *Mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation, *Treatment or disease which, according to the investigator, can affect treatment or study results., *Chronic malabsorption syndrome, *Participation or recent participation in a clinical study with an investigational product (within 30 days). Previous participation in this study., *Breast feeding, *Planned or known ongoing pregnancy, *Cholestasis, *Liver disease other than NAFLD, *Diabetes Mellitus treated with insulin, *Inflammatory bowel disease, *Irritable bowel disease
研究者
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