Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.
Overview
- Phase
- Not Applicable
- Intervention
- No clamp and placebo
- Conditions
- Osteoarthritis of Knee
- Sponsor
- Mahidol University
- Enrollment
- 240
- Primary Endpoint
- Postoperative blood loss
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
Total knee arthroplasty (TKA) may be associated with significant blood loss, and transfusion carries substantial risk of immunologic reaction and disease transmission. Several methods reportedly reduce postoperative blood loss and avoid homologous blood transfusion with traditional TKA approaches. Drain clamping was one of the widely used method and tranexamic acid administration was the recently adjuvant method to reduce blood loss in TKA. However, there were several regimens in either drain clamping or tranexamic acid administration reported in previous studies. Our objective was to compare the efficacy of our drain clamping protocol and/or tranexamic acid regimen for reducing blood loss and transfusion in TKA.
Investigators
Keerati Charoencholvanich
Associate Professor
Mahidol University
Eligibility Criteria
Inclusion Criteria
- •The patients younger than 85 years with knee osteoarthritis
Exclusion Criteria
- •The patient diagnosed secondary osteoarthritis (eg, rheumatoid arthritis, posttraumatic arthritis, gouty arthritis, postseptic arthritis)
- •High-risk medical comorbid patient
- •The patient who was planed for simultaneous bilateral TKAs
- •The patient who had history of thromboembolic disease or bleeding disorder
- •The patient who was receiving anticoagulant drug treatment
- •The patient who had allergy to tranexamic acid
Arms & Interventions
Group A
No clamp and placebo
Intervention: No clamp and placebo
Group B
Tranexamic acid
Intervention: Tranexamic acid
Group C
Drain clamping
Intervention: Drain clamping
Group D
Drain clamping and tranexamic acid
Intervention: Drain clamping and tranexamic acid
Outcomes
Primary Outcomes
Postoperative blood loss
Time Frame: 48 hours after operation
Secondary Outcomes
- Number of blood transfusion(5 days)