Estimate the time to blood culture positivity in neonates with sepsis a observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- The primary out come is to estimate the mean time to blood culture positivity in neonatal sepsis.
研究概览
简要总结
NEONATAL SEPSIS STANDS AS A SIGNIFICANT CONTRIBUTOR TO MORTALITY AND LONG TERM COMPLICATIONS IN BOTH DEVELOPED AND DEVELOPING COUNTRIES IT RANKS THE SECOND MAJOR CAUSE OF NEONATAL MORTALITY CLAIMING OVER A MILLION LIVES ANNUALLY ,WHILE CULTURE REMAINS THE GOLD STANDARD FOR DIAGNOSIS ITS POSITIVITY RATES ARE NOTABLY LOW AND VARIABLE RANGING FROM 10 TO 15 % EARLY IDENTIFICATION OF INFECTING ORGANISM IN THE BLOOD IS CRUCIAL FOR OPTIMIZING ANTIBACTERIAL TREATMENT . TIME TO POSITIVITY PROVIDES INDIRECT INFORMATION ON THE BIOMASS REFLECTING THE BACTERAEMIA LOAD AND MICROBIAL GROWTH RATE A LOWER TIME TO POSITIVITY INDICATES A FASTER POSITVE SIGNAL SUGGEST A HIGHER INOCULUM IN THE BLOOD AND / OR A FASTER GROWTH RATE.
THE AIM OF STUDY IS TO ESTIMATE THE IMPORTANCE OF TIME TO POSITIVITY AS A CRITICAL FACTOR INFLUENCING DECISION ABOUT ANTIBIOTIC TREATMENT AND ITS DURATION IN CHILDREN WITH SEPSIS
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 0.00 Day(s) 至 28.00 Day(s)（—）
- 性别
- All
入选标准
- •Neonates less than 28 days.
- •Clinical sepsis.
- •Parents or guardians who has given voluntary signed written and informed consent.
排除标准
- •Presence of central line or PICC peripherally inserted central catheter line.
- •Major congenital malformation.
结局指标
主要结局
The primary out come is to estimate the mean time to blood culture positivity in neonatal sepsis.
时间窗: Any time before discharge
次要结局
- Type of sepsis(Before Discharge)
- Sepsis markers like CRP & Procalcitonin(Before Discharge)
- Organism profile(Before Discharge)
- Shock(Before Discharge)
- Duration of hospital stay(Before Discharge)
- Mortality(Before Discharge)
研究者
Dr Murali M
Indira Gandhi Institute of Child Health, Bengaluru