Post-COVID-19 Monitoring in Routine Health Insurance Data
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 157,134
- 试验地点
- 1
- 主要终点
- Incidence of disorientation
研究概览
简要总结
The SARS-CoV-2 infection was in 2020 responsible for new disease related chronic conditions which have been referred to as Post-COVID. To date it is still unknown how common this condition is and which symptoms are related to it. The aim of the study is to monitor the onset of these conditions in a large observational study consisting of German health insurance data.
详细描述
SARS-CoV-2 is a virus of the coronavirus family, which includes a large number of viruses that can cause a wide variety of diseases in humans. The SARS-CoV-2 virus causes acute symptoms associated with the infection and can cause chronic conditions known as Post-COVID. To understand the prevalence and variety of Post-COVID a large observational study of health insurance data from Germany was set up. The exposed patients were identified by a diagnosis indicating a confirmed laboratory test for COVID.
The basic question concerns the burden of the Post-COVID condition. The study investigate which symptoms are more common in humans after the exposure to the virus compared to a matched unexposed cohort. Further will this be investigated in the subgroup of children and adolescents and those who have been hospitalized due to the virus infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least one outpatient or inpatient diagnosis of COVID-19 with laboratory detection of the virus (ICD-10: U07.1!)
- •Continuously insured with the respective health insurance between 2019-01-01/birth and 2020-12-31/death
排除标准
- 未提供
结局指标
主要结局
Incidence of disorientation
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of disorientation in outpatient or inpatient setting
Incidence of arthritides
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of arthritides in outpatient or inpatient setting
Incidence of behavioral symptoms
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of behavioral symptoms in outpatient or inpatient setting
Incidence of carditis due to viruses
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of carditis due to viruses in outpatient or inpatient setting
Incidence of changes in bowel habits
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of changes in bowel habits due to viruses in outpatient or inpatient setting
Incidence of cognitive function impairment
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of cognitive function impairment in outpatient or inpatient setting
Incidence of COVID toe
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of COVID toe in outpatient or inpatient setting
Incidence of facial nerve paralysis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of facial nerve paralysis in outpatient or inpatient setting
Incidence of anxiety disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of anxiety disorder in outpatient or inpatient setting
Incidence of abdominal pain
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of abdominal pain recorded in outpatient or inpatient setting
Incidence of acute pain
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of acute pain recorded in outpatient or inpatient setting
Incidence of ascites
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of ascites in outpatient or inpatient setting
Incidence of chronic fatigue syndrome
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of chronic fatigue syndrome in outpatient or inpatient setting
Incidence of cough
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of cough in outpatient or inpatient setting
Incidence of dyslexia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of dyslexia in in outpatient or inpatient setting
Incidence of hyperhidrosis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hyperhidrosis in outpatient or inpatient setting
Incidence of adjustment disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of adjustment disorder recorded in outpatient or inpatient setting
Incidence of anuria/oliguria
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of anuria/oliguria in outpatient or inpatient setting
Incidence of cachexia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of cachexia in outpatient or inpatient setting
Incidence of concentration impairment/concentration deficit
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of concentration impairment/concentration deficit in outpatient or inpatient setting
Incidence of depression
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of depression in outpatient or inpatient setting
Incidence of dysgeusia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of dysgeusia in outpatient or inpatient setting
Incidence of dysmenorrhea
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of dysmenorrhea in outpatient or inpatient setting
Incidence of dyspnea
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of dyspnea in outpatient or inpatient setting
Incidence of dysuria
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of dysuria in outpatient or inpatient setting
Incidence of emotional and behavioral disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of emotional and behavioral disorder in outpatient or inpatient setting
Incidence of epistaxis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of epistaxis in outpatient or inpatient setting
Incidence of eye pain
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of eye pain in outpatient or inpatient setting
Incidence of fever
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of fever in outpatient or inpatient setting
Incidence of nausea
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of nausea in outpatient or inpatient setting
Incidence of hearing loss/tinnitus
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hearing loss/tinnitus in outpatient or inpatient setting
Incidence of heart murmurs
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of heart murmurs in outpatient or inpatient setting
Incidence of heartburn
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of heartburn in outpatient or inpatient setting
Incidence of neurasthenia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of neurasthenia in outpatient or inpatient setting
Incidence of developmental delay
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of developmental delay in outpatient or inpatient setting
Incidence of dysphagia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of dysphagia in outpatient or inpatient setting
Incidence of gangrene
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of gangrene in outpatient or inpatient setting
Incidence of hemorrhage
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hemorrhage in outpatient or inpatient setting
Incidence of hoarseness
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hoarseness in outpatient or inpatient setting
Incidence of impaired balance
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of impaired balance in outpatient or inpatient setting
Incidence of meningismus
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of meningismus in outpatient or inpatient setting
Incidence of sopor/coma
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of sopor/coma in outpatient or inpatient setting
Incidence of hair loss
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hair loss in outpatient or inpatient setting
Incidence of headache
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of headache in outpatient or inpatient setting
Incidence of hypotension
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hypotension in outpatient or inpatient setting
Incidence of Malaise/fatigue/exhaustion
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of Malaise/fatigue/exhaustion in outpatient or inpatient setting
Incidence of myalgia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of myalgia in outpatient or inpatient setting
Incidence of myocarditis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of myocarditis in outpatient or inpatient setting
Incidence of other cardiac arrhythmias
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of other cardiac arrhythmias in outpatient or inpatient setting
Incidence of other symptoms of the urinary system
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of other symptoms of the urinary system in outpatient or inpatient setting
Incidence of pathological findings from male genital tract
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of pathological findings from male genital tract in outpatient or inpatient setting
Incidence of pathological reflexes
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of pathological reflexes in outpatient or inpatient setting
Incidence of seizures
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of seizures in outpatient or inpatient setting
Incidence of sensation and perception disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of sensation and perception disorder in outpatient or inpatient setting
Incidence of shock
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of shock in outpatient or inpatient setting
Incidence of somatization disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of somatization disorder in outpatient or inpatient setting
Incidence of flatulence
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of flatulence in outpatient or inpatient setting
Incidence of general symptoms
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of general symptoms in outpatient or inpatient setting
Incidence of myocardial infarction
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of myocardial infarction in outpatient or inpatient setting
Incidence of obsessive-compulsive disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of obsessive-compulsive disorder in outpatient or inpatient setting
Incidence of oedema
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of oedema in outpatient or inpatient setting
Incidence of paresthesia of skin
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of paresthesia of skin in outpatient or inpatient setting
Incidence of pericarditis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of pericarditis in outpatient or inpatient setting
Incidence of pulmonary embolism
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of pulmonary embolism in outpatient or inpatient setting
Incidence of respiratory insufficiency
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of respiratory insufficiency in outpatient or inpatient setting
Incidence of somnolence
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of somnolence in outpatient or inpatient setting
Incidence of heart failure
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of heart failure in outpatient or inpatient setting
Incidence of hepatomegaly and splenomegaly
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of hepatomegaly and splenomegaly in outpatient or inpatient setting
Incidence of joint pain
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of joint pain in outpatient or inpatient setting
Incidence of loss of appetite
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of Loss of appetite in outpatient or inpatient setting
Incidence of lymphadenopathy
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of lymphadenopathy in outpatient or inpatient setting
Incidence of memory impairment
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of memory impairment in outpatient or inpatient setting
Incidence of mood disorder
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of mood disorder in outpatient or inpatient setting
Incidence of movement disorders
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of movement disorders in outpatient or inpatient setting
Incidence of neurological manifestation of Post-COVID
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of Neurological manifestation of Post-COVID in outpatient or inpatient setting
Incidence of other coordination disorders/ataxia
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of other coordination disorders/ataxia in outpatient or inpatient setting
Incidence of pain, not elsewhere classified
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of pain, not elsewhere classified in outpatient or inpatient setting
Incidence of paresis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of paresis in outpatient or inpatient setting
Incidence of pathological lung findings
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of pathological lung findings from male genital tract in outpatient or inpatient setting
Incidence of polyuria
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of polyuria in outpatient or inpatient setting
Incidence of Post-COVID
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of Post-COVID in outpatient or inpatient setting
Incidence of rash
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of rash in outpatient or inpatient setting
Incidence of sinus vein thrombosis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of sinus vein thrombosis in outpatient or inpatient setting
Incidence of stroke
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of stroke in outpatient or inpatient setting
Incidence of throat/chest pain
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of throat/chest pain in outpatient or inpatient setting
Incidence of urinary retention
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of urinary retention in outpatient or inpatient setting
Incidence of vertigo
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of vertigo in outpatient or inpatient setting
Incidence of sleep disorders
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of sleep disorders in outpatient or inpatient setting
Incidence of speech and language disorders
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of speech and language disorders in outpatient or inpatient setting
Incidence of subcutaneous nodules
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of subcutaneous nodules in outpatient or inpatient setting
Incidence of syncope
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of syncope in outpatient or inpatient setting
Incidence of tetany
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of tetany in outpatient or inpatient setting
Incidence of weight gain/loss, eating disorders
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of weight gain/loss, eating disorders in outpatient or inpatient setting
Incidence of thrombosis
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of thrombosis in outpatient or inpatient setting
Incidence of urethral discharge
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of urethral discharge in outpatient or inpatient setting
Incidence of visual disturbances
时间窗: At least 12 weeks after the infection by SARS-CoV-2
Incidence of a diagnosis of visual disturbances in outpatient or inpatient setting
次要结局
未报告次要终点
研究者
Falko Tesch
Principal Investigator
Technische Universität Dresden