Non-hypovascular Solid Pancreatic Lesions: Role of EUS

Completed

• Conditions: Solid Pancreatic Neoplasms; Endoscopic Ultrasound

• Registration Number: NCT03738280
• Lead Sponsor: Azienda Ospedaliera Universitaria Integrata Verona

Brief Summary

Vascular pattern of solid pancreatic lesions (SPLs) has been investigated by different abdominal imaging modalities and by contrast-enhanced endoscopic ultrasonography (CE-EUS). Compared with surrounding pancreatic parenchyma three different patterns have been described: hypo-, iso-, and hypervascular. The majority of SPLs are hypovascular, and the diagnostic relevance of hypoenhanced pattern to predict pancreatic adenocarcinoma (PDAC) is well established. Differently, iso- and hypervascular pattern is not specific and can be expressed by several SPLs, with different clinical behavior and management. To date, poor is know about the role of EUS in differential diagnosis of non-hypovascular SPLs and features associated with malignancy.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-01
• Primary Completion: 2018-05
• Study First Submitted: 2018-11-08
• Study First Submitted QC: 2018-11-09
• Study First Posted: 2018-11-13
• Status Verified: 2019-05
• Study Completion: 2019-05
• Last Update Submitted: 2019-05-05
• Last Update Posted: 2019-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

• Presence of one or more solid pancreatic lesions preliminary evaluated by contrast-enhanced computed tomography (CE-CT) and/or contrast enhanced magnetic resonance imaging (CE-MRI) reporting a non-hypovascular contrast pattern (e.g., iso- or hypervascular).

Exclusion Criteria

• Patients with associated chronic pancreatitis features (e.g., pancreatic calcifications)
• Lesion with hypovascular pattern at CE-EUS.
• Lesion not found or non pancreatic at EUS.
• Patients refusing to be included in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Upstream dilation of the main pancreatic duct	6 months	Percentage of cases with upstream dilation of main pancreatic duct will be recorded.
Lesion borders (smooth or irregular)	6 months	Percentage of cases with smooth or irregular borders will be recorded.
Vascular pattern (iso or hypervascular)	6 months	Percentage of cases with iso-vascular or hyper-vascular pattern will be recorded.

Trial Locations

Locations (1)

Stefano Francesco Crinò; 🇮🇹 Verona, VR, Italy