Role of EUS in Differential Diagnosis and Malignancy Prediction of Non-hypovascular Solid Pancreatic Lesions: A Prospective Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Solid Pancreatic Neoplasms
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
- Enrollment
- 154
- Locations
- 1
- Primary Endpoint
- Upstream dilation of the main pancreatic duct
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Vascular pattern of solid pancreatic lesions (SPLs) has been investigated by different abdominal imaging modalities and by contrast-enhanced endoscopic ultrasonography (CE-EUS). Compared with surrounding pancreatic parenchyma three different patterns have been described: hypo-, iso-, and hypervascular. The majority of SPLs are hypovascular, and the diagnostic relevance of hypoenhanced pattern to predict pancreatic adenocarcinoma (PDAC) is well established. Differently, iso- and hypervascular pattern is not specific and can be expressed by several SPLs, with different clinical behavior and management. To date, poor is know about the role of EUS in differential diagnosis of non-hypovascular SPLs and features associated with malignancy.
Investigators
Stefano Francesco Crinò, MD
Principal Investigator
Azienda Ospedaliera Universitaria Integrata Verona
Eligibility Criteria
Inclusion Criteria
- •Presence of one or more solid pancreatic lesions preliminary evaluated by contrast-enhanced computed tomography (CE-CT) and/or contrast enhanced magnetic resonance imaging (CE-MRI) reporting a non-hypovascular contrast pattern (e.g., iso- or hypervascular).
Exclusion Criteria
- •Patients with associated chronic pancreatitis features (e.g., pancreatic calcifications)
- •Lesion with hypovascular pattern at CE-EUS.
- •Lesion not found or non pancreatic at EUS.
- •Patients refusing to be included in the study
Outcomes
Primary Outcomes
Upstream dilation of the main pancreatic duct
Time Frame: 6 months
Percentage of cases with upstream dilation of main pancreatic duct will be recorded.
Lesion borders (smooth or irregular)
Time Frame: 6 months
Percentage of cases with smooth or irregular borders will be recorded.
Vascular pattern (iso or hypervascular)
Time Frame: 6 months
Percentage of cases with iso-vascular or hyper-vascular pattern will be recorded.