Comparative study of pharmacokinetics of amlodipine besilate oral liquid and tablets in healthy Dutch volunteers.
Completed
- Conditions
- Pharmacokinetics, hypertension, amlodipine besilate, oral liquid. Farmacokinetiek, hypertensie, amlodipine besilaat, orale drank.
- Registration Number
- NL-OMON23706
- Lead Sponsor
- Erasmus Medical Centrees Gravendijkwal 230, 3015 CE Rotterdam, The NetherlandsPhone: +31(0) 10-7040704
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1. Subject is healthy;
2. Subject is Caucasian;
Exclusion Criteria
1. Sitting blood pressure lower than 120 mmHg systolic and/or 80 mmHg diastolic in resting conditions;
2. Use of medication, both medicines on prescription and over-the-counter medicines, excluding contraceptives;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The pharmacokinetic parameters Cmax, tmax, AUC0-72, AUC‡ of amlodipine besilate oral liquid 0,5 mg/ml and Norvasc tablets 5 mg will be assessed.
- Secondary Outcome Measures
Name Time Method Secondary, the taste of the amlodipine besilate oral liquid 0,5 mg/ml will to be determined using a questionnaire.