Participation to Colorectal Cancer Screening With Faecal Occult Blood Test and Colonoscopy: an Italian, Multicenter, Randomized Population Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colorectal Cancer
- Sponsor
- Istituto Superiore di Sanità
- Enrollment
- 9889
- Locations
- 1
- Primary Endpoint
- Participation to colorectal cancer screening
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
Adherence rate to screening colonoscopy (TC) in the average-risk general population is still unclear. Aim of this study was to compare the uptake of TC screening with that of fecal occult blood (FOBT) in the general population of different Italian areas.
Detailed Description
A nationwide, population-based, multicenter, randomized trial comparing attendance to TC with that to FOBT was performed. Sixty-four general practitioners (GPs), overall including in their lists 9,889 average-risk subjects aged 55-64 years, were randomized between TC and FOBT screening programs. Eligible subjects were mailed a personal invitation letter co-signed by their GP and the coordinator of the area-reference GI centre. Attendance rate and detection rate for advanced neoplasia (colorectal cancer, adenoma \>10 mm or with villous histology or high-grade dysplasia) for each arm of the study were assessed.
Investigators
Eligibility Criteria
Inclusion Criteria
- •asymptomatic 55-64 years subjects
Exclusion Criteria
- •already studied for colorectal cancer, severe comorbidities
Outcomes
Primary Outcomes
Participation to colorectal cancer screening