MIDNOR-TIA - a Study of 600 Patients With Transient Ischemic Attack
- Conditions
- Ischemic Attack, TransientStroke
- Registration Number
- NCT02038725
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
Patients with a transient ischemic attack (TIA) are at high risk of stroke. Rapid assessment and treatment can reduce the risk. Several international guidelines recommend a test, the ABCD2 score, to identify TIA patients with low and high risk for stroke. The main purpose of this study is to investigate stroke risk after TIA in both short (1 week) and long term (3 months/1 year), and to assess whether the ABCD2 score ('Age, blood pressure, clinical features, duration of TIA, diabetes score) is an adequate tool for predicting stroke risk. Secondary aims are to explore whether adopting imaging modalities (ultrasound, MRI) and biological markers of blood into a risk score could improve the predictive value of the ABCD2 score and still be feasible in a daily clinical practice. Further on overall risk factors in TIA patients, and the incidence of other vascular events will be studied. A substudy designed as a randomised controlled trial evaluates pharmaceutical counseling in a subset of participants. Cost-benefit analysis, and a long-term follow-up (5 years) is planned.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 584
- Probable or possible transient ischemic attack
- Residing in Central Norway
- Examined within 2 weeks after the onset of symptoms
- Modified Rankin Scale 3 or less and living at home
- Informed consent
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of patients presenting with stroke within 1 week after transient ischemic attack 1 week Measured by using data from the Norwegian Stroke Registry
- Secondary Outcome Measures
Name Time Method Incidence of other vascular events within 3 months after transient ischemic attack 3 months Measured by using data from national health registries
Incidence of other vascular events within 1 year after transient ischemic attack 1 year Measured by using data from national health registries
Number of patients presenting with stroke within 3 months after transient ischemic attack 3 months Measured by using data from the Norwegian Stroke Registry
Correlation between the ABCD2 score and the incidence of stroke within 3 months after transient ischemic attack 3 months Measured by comparing the ABCD2 score and the incidence of stroke within 3 months after transient ischemic attack based on data from the Norwegian Stroke Registry
Incidence of other vascular events within 1 week after transient ischemic attack 1 week Measured by using data from national health registries
Number of patients presenting with stroke within 1 year after transient ischemic attack 1 year Measured by using data from the Norwegian Stroke Registry
Cost-benefit analysis 1 year Economic analysis that compares the costs of admission to hospital versus outpatient assessment of patients who have had transient ischemic attacks
Correlation between the ABCD2 score and the incidence of stroke within 1 week after transient ischemic attack 1 week Measured by comparing the ABCD2 score and the incidence of stroke within 1 week after transient ischemic attack based on data from the Norwegian Stroke Registry
Correlation between the ABCD2 score and the incidence of stroke within 1 year after transient ischemic attack 1 year Measured by comparing the ABCD2 score and the incidence of stroke within 1 year after transient ischemic attack based on data from the Norwegian Stroke Registry
Trial Locations
- Locations (8)
Orkdal Sykehus
🇳🇴Orkanger, Norway
Molde Sykehus
🇳🇴Molde, Norway
Volda Sykehus
🇳🇴Volda, Norway
Levanger Sykehus
🇳🇴Levanger, Norway
Namsos Sykehus
🇳🇴Namsos, Norway
Ålesund Sykehus
🇳🇴Ålesund, Norway
Kristiansund Sykehus
🇳🇴Kristiansund, Norway
St Olavs Hospital
🇳🇴Trondheim, Norway