NCT00672269Unknown不适用
A Pilot Study to Investigate Germ-Line MEN1 and SDHD Gene Mutation in Familial Cases of Carcinoid Cancer
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Mutations in MEN1 and SDHD genes
研究概览
简要总结
There is a high incidence among the first degree relatives of the carcinoid patients, indicating the involvement of genetic components in its initiation and pathogenesis.
详细描述
This proposed pilot study will conduct detailed interviews into the medical, environmental, and family histories and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Over the age of 18 years
- •More than one ,member of a family with a history of biopsy confirmed carcinoid tumor
- •English speaking
- •Mentally and emotionally capable of answering questions
- •Willing and available for study participation
- •At least one other family member with carcinoid tumor
排除标准
- •If you are under the age of 18 years,
- •If you are unable to understand or unable to provide informed consent,
- •If you have a psychological condition (i.e. depression, anxiety disorder, substance abuse, etc.) which might cause you significant problems in dealing with test results.
结局指标
主要结局
Mutations in MEN1 and SDHD genes
时间窗: 1 year
次要结局
未报告次要终点
研究者
研究点 (1)
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